MetaCyc Pathway: superpathway of histidine, purine, and pyrimidine biosynthesis

Pathway diagram: superpathway of histidine, purine, and pyrimidine biosynthesis

If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: Superpathways

Some taxa known to possess this pathway include : Escherichia coli K-12 substr. MG1655

Expected Taxonomic Range: Bacteria

Pyrimidine, purine, and pyridine nucleotide synthesis all require phosphoribosylpyrophosphate (PRPP) as a precursor. PRPP is utilized by both the de novo pathways and the auxiliary or salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates by phosphoribosyltransferases. PRPP is also used in the histidine and tryptophan biosynthesis pathways. PRPP thus may be regarded as a precursor for the synthesis of nucleic acids, proteins, and for the NAD(P) coenzymes. The formation of PRPP therefore is subjected to strict metabolic control [HoveJensen86].

Subpathways: adenosine ribonucleotides de novo biosynthesis, adenosine deoxyribonucleotides de novo biosynthesis II, 5-aminoimidazole ribonucleotide biosynthesis II, inosine-5'-phosphate biosynthesis I, superpathway of adenosine nucleotides de novo biosynthesis II, superpathway of guanosine nucleotides de novo biosynthesis II, guanosine deoxyribonucleotides de novo biosynthesis II, guanosine ribonucleotides de novo biosynthesis, L-histidine biosynthesis, superpathway of purine nucleotides de novo biosynthesis II, superpathway of pyrimidine ribonucleotides de novo biosynthesis, PRPP biosynthesis II, PRPP biosynthesis I, UTP and CTP de novo biosynthesis, UMP biosynthesis

Unification Links: EcoCyc:PRPP-PWY


HoveJensen86: Hove-Jensen B, Harlow KW, King CJ, Switzer RL (1986). "Phosphoribosylpyrophosphate synthetase of Escherichia coli. Properties of the purified enzyme and primary structure of the prs gene." J Biol Chem 1986;261(15);6765-71. PMID: 3009477

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Abbott06: Abbott JL, Newell JM, Lightcap CM, Olanich ME, Loughlin DT, Weller MA, Lam G, Pollack S, Patton WA (2006). "The Effects of Removing the GAT Domain from E. coli GMP Synthetase." Protein J 25;483-491. PMID: 17103135

Abrahams94: Abrahams JP, Leslie AG, Lutter R, Walker JE (1994). "Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria." Nature 370(6491);621-8. PMID: 8065448

Adams54: Adams E (1954). "The enzymatic synthesis of histidine from histidinol." J Biol Chem 209(2);829-46. PMID: 13192138

Adams55: Adams E (1955). "L-Histidinal, a biosynthetic precursor of histidine." J Biol Chem 217(1);325-44. PMID: 13271397

Aghajari94: Aghajari N, Jensen KF, Gajhede M (1994). "Crystallization and preliminary X-ray diffraction studies on the Apo form of orotate phosphoribosyltransferase from Escherichia coli." J Mol Biol 241(2);292-4. PMID: 8057372

Ahmad69: Ahmad SI, Pritchard RH (1969). "A map of four genes specifying enzymes involved in catabolism of nucleosides and deoxynucleosides in Escherichia coli." Mol Gen Genet 104(4);351-9. PMID: 4904508

Ahmad79: Ahmad SI, Eisenstark A (1979). "Thymidine sensitivity of certain strains of Escherichia coli K12." Mol Gen Genet 172(2);229-31. PMID: 384146

Aiba89: Aiba A, Mizobuchi K (1989). "Nucleotide sequence analysis of genes purH and purD involved in the de novo purine nucleotide biosynthesis of Escherichia coli." J Biol Chem 1989;264(35);21239-46. PMID: 2687276

Aksimentiev04: Aksimentiev A, Balabin IA, Fillingame RH, Schulten K (2004). "Insights into the molecular mechanism of rotation in the Fo sector of ATP synthase." Biophys J 86(3);1332-44. PMID: 14990464

Alam04: Alam N, Stieglitz KA, Caban MD, Gourinath S, Tsuruta H, Kantrowitz ER (2004). "240s loop interactions stabilize the T state of Escherichia coli aspartate transcarbamoylase." J Biol Chem 279(22);23302-10. PMID: 15014067

Albrechtsen80: Albrechtsen H, Ahmad SI (1980). "Regulation of the synthesis of nucleoside catabolic enzymes in Escherichia coli: further analysis of a deo Oc mutant strain." Mol Gen Genet 1980;179(2);457-60. PMID: 6780756

Alenin92: Alenin VV, Ostanin KV, Kostikova TR, Domkin VD, Zubova VA, Smirnov MN (1992). "[Substrate specificity of phosphoribosyl-aminoimidazole-succinocarboxamide synthetase (SAICAR-synthetase) from Saccharomyces cerevisiae yeast]." Biokhimiia 1992;57(6);845-55. PMID: 1420588

Allard92: Allard P, Kuprin S, Shen B, Ehrenberg A (1992). "Binding of the competitive inhibitor dCDP to ribonucleoside-diphosphate reductase from Escherichia coli studied by 1H NMR. Different properties of the large protein subunit and the holoenzyme." Eur J Biochem 1992;208(3);635-42. PMID: 1396671

Almaula95: Almaula N, Lu Q, Delgado J, Belkin S, Inouye M (1995). "Nucleoside diphosphate kinase from Escherichia coli." J Bacteriol 177(9);2524-9. PMID: 7730286

alShawi92: al-Shawi MK, Senior AE (1992). "Catalytic sites of Escherichia coli F1-ATPase. Characterization of unisite catalysis at varied pH." Biochemistry 31(3);878-85. PMID: 1531027

Aluri15: Aluri S, Rex K, Varshney U (2015). "Simultaneous presence of fhs and purT genes is disadvantageous for the fitness of Escherichia coli growth." FEMS Microbiol Lett 362(14). PMID: 26100103

Anand04: Anand R, Hoskins AA, Stubbe J, Ealick SE (2004). "Domain organization of Salmonella typhimurium formylglycinamide ribonucleotide amidotransferase revealed by X-ray crystallography." Biochemistry 43(32);10328-42. PMID: 15301531

Andersen91: Andersen JT, Jensen KF, Poulsen P (1991). "Role of transcription pausing in the control of the pyrE attenuator in Escherichia coli." Mol Microbiol 5(2);327-33. PMID: 1710313

Anderson75: Anderson PM, Carlson JD (1975). "Reversible reaction of cyanate with a reactive sulfhydryl group at the glutamine binding site of carbamyl phosphate synthetase." Biochemistry 1975;14(16);3688-94. PMID: 240389

Anderson77: Anderson PM (1977). "Binding of allosteric effectors to carbamyl-phosphate synthetase from Escherichia coli." Biochemistry 1977;16(4);587-93. PMID: 189806

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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