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MetaCyc Pathway: indole-3-acetate activation I
Inferred from experiment

Pathway diagram: indole-3-acetate activation I

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Synonyms: IAA biosynthesis from amide-conjugates, IAA deconjugation, indole-3-acetic acid biosynthesis from amide-conjugates, IAA activation I

Superclasses: Activation/Inactivation/InterconversionActivation
BiosynthesisHormones BiosynthesisPlant Hormones BiosynthesisAuxins Biosynthesis

Some taxa known to possess this pathway include : Arabidopsis thaliana col

Expected Taxonomic Range: Viridiplantae

The phytohormone family of auxins regulates many plant biological processes including cell division, elongation, differentiation, root initiation, tropic responses, flowering, fruit ripening, and senescence [Woodward05]. Indole-3-acetic acid (IAA) is the most abundant natural plant auxin.

In addition to de novo synthesis, IAA can be released from its conjugates. In Arabidopsis, the naturally occurring IAA amide conjugates indole-3-acetyl-leucine and indole-3-acetyl-alanine have been reported to be hydrolyzed to release free IAA [Bartel01, Kowalczyk].

Variants: indole-3-acetate activation II, indole-3-acetate biosynthesis I, indole-3-acetate biosynthesis II, indole-3-acetate biosynthesis III (bacteria), indole-3-acetate biosynthesis IV (bacteria), indole-3-acetate biosynthesis V (bacteria and fungi), L-tryptophan degradation VII (via indole-3-pyruvate), methyl indole-3-acetate interconversion

Unification Links: AraCyc:PWY-1822


Bartel01: Bartel, Bonnie, LeClere, Sherry, Magidin, Monica, Zolman, Bethany "Inputs to the active indole-3-acetic acid pool: de novo synthesis, conjugate hydrolysis, and indole-3-butyric acid beta-oxidation." Journal of Plant Growth Regulation (2001) 20:198-216.

Bartel95: Bartel B, Fink GR (1995). "ILR1, an amidohydrolase that releases active indole-3-acetic acid from conjugates." Science 268(5218);1745-8. PMID: 7792599

Davies99: Davies RT, Goetz DH, Lasswell J, Anderson MN, Bartel B (1999). "IAR3 encodes an auxin conjugate hydrolase from Arabidopsis." Plant Cell 11(3);365-76. PMID: 10072397

Kowalczyk: Kowalczyk, Mariusz "Metabolism and homeostasis of indole-3-acetic acid in Arabidopsis thaliana." Doctoral diss. Dept. of Forest Genetics and Plant Physiol., SLU. Acta Universitatis Agriculturae Sueciae. Silvestria Vol. 256.

Woodward05: Woodward AW, Bartel B (2005). "Auxin: regulation, action, and interaction." Ann Bot (Lond) 95(5);707-35. PMID: 15749753

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

LeClere02: LeClere S, Tellez R, Rampey RA, Matsuda SP, Bartel B (2002). "Characterization of a family of IAA-amino acid conjugate hydrolases from Arabidopsis." J Biol Chem 277(23);20446-52. PMID: 11923288

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Sat Apr 30, 2016, BIOCYC11A.