Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store

MetaCyc Pathway: cytokinins degradation
Inferred from experiment

Enzyme View:

Pathway diagram: cytokinins degradation

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Synonyms: Cytokinins oxidation

Superclasses: Degradation/Utilization/AssimilationHormones DegradationPlant Hormones DegradationCytokinins Degradation
Metabolic Clusters

Some taxa known to possess this pathway include : Arabidopsis thaliana col, Zea mays

Expected Taxonomic Range: Viridiplantae

Cytokinins, which are N6-substituted purine derivatives, are a class of plant hormones that plays important physiological roles in plants, from promotion of cell division, to release of lateral buds from apical dominance or delay of senescence. Cytokinin homeostasis is regulated by the rate of biosynthesis, import, conjugation (mainly in the form of glycosides) and degradation. Cytokinins are irreversibly degraded by cytokinin oxidases which catalyse cleavage of the N6-isopentenyl-side chain resulting in formation of adenine-type compounds. Cytokinins isopentenyladenine, zeatins and their ribosides are cleaved in a single enzymatic step by oxidative side chain cleavage. This activity has been recorded in many plants and is thought to plant a key role in controlling cytokinin levels in plants.

Citations: [Bilyeu01, Schmulling03]

Unification Links: AraCyc:PWY-2841


Bilyeu01: Bilyeu KD, Cole JL, Laskey JG, Riekhof WR, Esparza TJ, Kramer MD, Morris RO (2001). "Molecular and biochemical characterization of a cytokinin oxidase from maize." Plant Physiol 125(1);378-86. PMID: 11154345

Schmulling03: Schmulling T, Werner T, Riefler M, Krupkova E, Bartrina y Manns I (2003). "Structure and function of cytokinin oxidase/dehydrogenase genes of maize, rice, Arabidopsis and other species." J Plant Res 116(3);241-52. PMID: 12721786

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Kakimoto01: Kakimoto T (2001). "Identification of plant cytokinin biosynthetic enzymes as dimethylallyl diphosphate:ATP/ADP isopentenyltransferases." Plant Cell Physiol 42(7);677-85. PMID: 11479373

Kasahara04: Kasahara H, Takei K, Ueda N, Hishiyama S, Yamaya T, Kamiya Y, Yamaguchi S, Sakakibara H (2004). "Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis." J Biol Chem 279(14);14049-54. PMID: 14726522

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nouws75: Nouws JF (1975). "[Distribution of Rifamycin SV in de Bovine Tissues Following Intramammary Administration of Rifamastene (author's transl)]." Tijdschr Diergeneeskd 100(10);539-45. PMID: 1154345

Takei04: Takei K, Yamaya T, Sakakibara H (2004). "Arabidopsis CYP735A1 and CYP735A2 encode cytokinin hydroxylases that catalyze the biosynthesis of trans-Zeatin." J Biol Chem 279(40);41866-72. PMID: 15280363

Werner03: Werner T, Motyka V, Laucou V, Smets R, Van Onckelen H, Schmulling T (2003). "Cytokinin-deficient transgenic Arabidopsis plants show multiple developmental alterations indicating opposite functions of cytokinins in the regulation of shoot and root meristem activity." Plant Cell 15(11);2532-50. PMID: 14555694

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Fri Apr 29, 2016, biocyc14.