If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Superclasses:||Biosynthesis → Cofactors, Prosthetic Groups, Electron Carriers Biosynthesis → NAD Metabolism → NAD Biosynthesis|
Some taxa known to possess this pathway include : Saccharomyces cerevisiae
Expected Taxonomic Range: Eukaryota
NAD is an ubiquitous molecule that participates in many metabolic reactions. It also plays important roles in transcriptional regulation, longevity, calorie-restriction-mediated life-span extension and age-associated diseases. In yeast, it has been shown that NAD affects longevity and transcriptional silencing through the regulation of the Sir2p family of NAD-dependent deacetylases [Lin03b, Lin04b].
NAD is synthesised via two major pathways in eukaryotic systems. In the de novo pathway (NAD biosynthesis II (from tryptophan)), the nicotinic acid moiety of NAD is synthesized from tryptophan via the kynurenine pathway. In yeast, the de novo pathway consists of six enzymatic steps (catalyzed by the products of the BNA genes) and one non-enzymatic reaction.
The two pathways converge at nicotinate nucleotide, and continue along the same path, generating NAD via deamido-NAD.
Subpathways: NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde , tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde , NAD biosynthesis II (from tryptophan) , NAD salvage pathway I
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