This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Superclasses:||Degradation/Utilization/Assimilation → Carbohydrates Degradation → Sugars Degradation → Sucrose Degradation|
Invertase activity is found in the cytoplasm, vacuole, and apoplast (see sucrose degradation III (sucrose invertase)), whereas sucrose cleavage by sucrose synthase is only found in the cytoplasm [Dey97a].
Sucrose synthase is a homotetrameric enzyme that catalyzes the reversible UDP-dependent cleavage of sucrose into UDP-glucose and fructose. Hexoses derived from sucrose degradation are used in a variety of important metabolic pathways including glycolysis, starch biosynthesis and the synthesis of cellulose and callose [Zhang99b].
Superpathways: superpathway of anaerobic sucrose degradation
Variants: sucrose degradation I (sucrose phosphotransferase) , sucrose degradation III (sucrose invertase) , sucrose degradation IV (sucrose phosphorylase) , sucrose degradation V (sucrose α-glucosidase) , sucrose degradation VII (sucrose 3-dehydrogenase)
Unification Links: AraCyc:PWY-3801
Zhang99b: Zhang XQ, Lund AA, Sarath G, Cerny RL, Roberts DM, Chollet R (1999). "Soybean nodule sucrose synthase (nodulin-100): further analysis of its phosphorylation using recombinant and authentic root-nodule enzymes." Arch Biochem Biophys 371(1);70-82. PMID: 10525291
Accorsi89: Accorsi A, Piatti E, Piacentini MP, Gini S, Fazi A (1989). "Isoenzymes of phosphoglucomutase from human red blood cells: isolation and kinetic properties." Prep Biochem 19(3);251-71. PMID: 2533352
AngelesNunez10: Angeles-Nunez JG, Tiessen A (2010). "Arabidopsis sucrose synthase 2 and 3 modulate metabolic homeostasis and direct carbon towards starch synthesis in developing seeds." Planta 232(3);701-18. PMID: 20559653
Bertrand76: Bertrand O, Kahn A, Cottreau D, Boivin P (1976). "Human leukocyte glucose-phosphate-isomerase purification by affinity elution and immunological study." Biochimie 58(3);261-7. PMID: 819039
Bieniawska07: Bieniawska Z, Paul Barratt DH, Garlick AP, Thole V, Kruger NJ, Martin C, Zrenner R, Smith AM (2007). "Analysis of the sucrose synthase gene family in Arabidopsis." Plant J 49(5);810-28. PMID: 17257168
But: But SIu, Khmelina VN, Mustakhimova II, Trotsenko IuA "[Production and characterization of Methylomicrobium alcaliphilum 20Z knockout mutants, which has sucrose and ectoin synthesis defective genes]." Mikrobiologiia 82(2);251-3. PMID: 23808151
But13: But SY, Khmelenina VN, Reshetnikov AS, Trotsenko YA (2013). "Bifunctional sucrose phosphate synthase/phosphatase is involved in the sucrose biosynthesis by Methylobacillus flagellatus KT." FEMS Microbiol Lett. PMID: 23865613
Caescu04: Caescu CI, Vidal O, Krzewinski F, Artenie V, Bouquelet S (2004). "Bifidobacterium longum requires a fructokinase (Frk; ATP:D-fructose 6-phosphotransferase, EC 220.127.116.11) for fructose catabolism." J Bacteriol 186(19);6515-25. PMID: 15375133
Ciereszko01: Ciereszko I, Johansson H, Hurry V, Kleczkowski LA (2001). "Phosphate status affects the gene expression, protein content and enzymatic activity of UDP-glucose pyrophosphorylase in wild-type and pho mutants of Arabidopsis." Planta 2001;212(4);598-605. PMID: 11525517
Csutora05: Csutora P, Strassz A, Boldizsar F, Nemeth P, Sipos K, Aiello DP, Bedwell DM, Miseta A (2005). "Inhibition of phosphoglucomutase activity by lithium alters cellular calcium homeostasis and signaling in Saccharomyces cerevisiae." Am J Physiol Cell Physiol 289(1);C58-67. PMID: 15703203
Dai06: Dai N, Petreikov M, Portnoy V, Katzir N, Pharr DM, Schaffer AA (2006). "Cloning and expression analysis of a UDP-galactose/glucose pyrophosphorylase from melon fruit provides evidence for the major metabolic pathway of galactose metabolism in raffinose oligosaccharide metabolizing plants." Plant Physiol 142(1);294-304. PMID: 16829585
Dai99: Dai N, Schaffer A, Petreikov M, Shahak Y, Giller Y, Ratner K, Levine A, Granot D (1999). "Overexpression of Arabidopsis hexokinase in tomato plants inhibits growth, reduces photosynthesis, and induces rapid senescence." Plant Cell 11(7);1253-66. PMID: 10402427
Damerow10: Damerow S, Lamerz AC, Haselhorst T, Fuhring J, Zarnovican P, von Itzstein M, Routier FH (2010). "Leishmania UDP-sugar pyrophosphorylase: the missing link in galactose salvage?." J Biol Chem 285(2);878-87. PMID: 19906649
Daran95: Daran JM, Dallies N, Thines-Sempoux D, Paquet V, Francois J (1995). "Genetic and biochemical characterization of the UGP1 gene encoding the UDP-glucose pyrophosphorylase from Saccharomyces cerevisiae." Eur J Biochem 233(2);520-30. PMID: 7588797
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