Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Pathway: β-alanine biosynthesis I

Enzyme View:

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Synonyms: β-alanine biosynthesis from polyamines

Superclasses: Biosynthesis Amino Acids Biosynthesis Individual Amino Acids Biosynthesis beta Alanine Biosynthesis

Some taxa known to possess this pathway include ? : Arabidopsis thaliana col , Glycine max , Hordeum vulgare , Setaria italica , Solanum lycopersicum , Triticum aestivum , Zea mays

Expected Taxonomic Range: Viridiplantae

Summary:
General Background

β-Alanine is a central component of pantothenate biosynthesis. In bacteria the synthesis of β-alanine occurs through the decarboxylation of L-aspartate (see β-alanine biosynthesis III). This route of biosynthesis however appears to be unique to prokaryotes and absent in eukaryotes. In several plants species as well as yeast β-alanine was shown to be derived from the degradation of polyamines such as spermine and spermidine. Radiotracer experiments in Zea mays showed that maize shoots can convert spermidine and spermine to β-alanine and its biosynthesis intermediate 1,3-diaminopropane [Terano78]. Similarly fruit pericarp discs of tomato (Solanum lycopersicum) were shown to catabolize radiolabeled spermidine to putrescine and β-alanine [Rastogi89].

Variants: β-alanine biosynthesis II , β-alanine biosynthesis III , β-alanine biosynthesis IV , uracil degradation I (reductive)

Unification Links: AraCyc:PWY-3981


References

Rastogi89: Rastogi R., Davies P.J. "Polyamine metabolism in ripening tomato fruit." Plant Physiol. (1989) 94 : 1449-1455.

Terano78: Terano S., Suzuki Y. "Formation of β-alanine from spermine and spermidine in maize shoots." Phytochemistry (1978) 17 : 148-149.

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Awal95: Awal H.M.A., Yoshida I., Doe M., Hirasawa E. "3-Aminopropionaldehyde dehydrogenase of millet shoot." Phytochemistry (1995) 40(2) : 393-395.

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Suzuki96a: Suzuki Y. "Purification and characterization of diamine oxidase from Triticum aesticum shoots." Phytochemistry (1996) 42(2) : 291-293.

Tanaka01: Tanaka K, Matsuno E, Shimizu E, Shibai H, Yorifuji T (2001). "Purification and characterization of aminopropionaldehyde dehydrogenase from Arthrobacter sp. TMP-1." FEMS Microbiol Lett 195(2);191-6. PMID: 11179651


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 18, 2014, biocyc13.