MetaCyc Pathway: L-asparagine degradation II
Inferred from experiment

Enzyme View:

Pathway diagram: L-asparagine degradation II

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: Degradation/Utilization/AssimilationAmino Acids DegradationProteinogenic Amino Acids DegradationL-asparagine Degradation

Some taxa known to possess this pathway include : Glycine max, Pisum sativum

Expected Taxonomic Range: Embryophyta

Asparagine is the first amino acid discovered in plants, where it is the major nitrogen transport and storage compound. In plants, asparagine is metabolized in two routes, via asparaginase ( L-asparagine degradation I) or via asparagine aminotransferase (this pathway). Studies in pea suggested that the predominant route differs in different tissues. The asparaginase pathway predominates in seeds, whereas the aminotransferase pathway predominates in leaves [Ireland81].

In the asparagine aminotransferase pathway, the product 2-oxosuccinamate could either be reduced to 2-hydroxysuccinamate or deaminated to oxaloacetate. 2-oxosuccinamate deaminase activity was co-detected with asparagine aminotransferase in soybean leaves [Streeter77]. Whereas, feeding experiment using pea leaves showed a high amount of 2- hydroxysuccinamate formed from asparagines [Lloyd78]. It is not clear which path is more relevant and the consequent reactions that further metabolize 2-hydroxysuccinamate [Ireland83].

Variants: L-asparagine degradation I, L-asparagine degradation III (mammalian)


Ireland81: Ireland, Robert, Joy, Kenneth "Two routes for asparagine metabolism in Pisum sativum." Planta, 1981, 151:289-292.

Ireland83: Ireland RJ, Joy KW (1983). "Purification and properties of an asparagine aminotransferase from Pisum sativum leaves." Arch Biochem Biophys 223(1);291-6. PMID: 6407397

Lloyd78: Lloyd, N.D.H., Joy, K.W. "2-hydroxysuccinamic acid: a product of asparagine metabolism in plants." Biochem. Biophys. Res. Commun. 1978, 81:186-192.

Streeter77: Streeter, John "Asparaginase and asparagine transaminase in soybean leaves and root nodules." Plant Physiology, 1977, 60:235-239.

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Fri Nov 27, 2015, biocyc11.