MetaCyc Pathway: L-proline biosynthesis IV
Inferred from experiment

Enzyme View:

Pathway diagram: L-proline biosynthesis IV

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: BiosynthesisAmino Acids BiosynthesisProteinogenic Amino Acids BiosynthesisL-proline Biosynthesis

Some taxa known to possess this pathway include : Datura stramonium, Lupinus angustifolius, Nicotiana tabacum

Expected Taxonomic Range: Viridiplantae

In plants proline can be synthesized from either glutamate [ L-proline biosynthesis I] or ornithine [ L-proline biosynthesis III]. In addition to the route from ornithine to proline described in [ L-proline biosynthesis III] (via L-glutamate-5-semialdehyde and (S)-1-pyrroline-5-carboxylate), an additional route is believed to exist, as depicted in here.

In this alternative ornithine route, the α-amino group of ornithine is lost, (opposed to the δ-amino group in the other route), giving rise to 2-keto-ornithine, which is then converted to proline via 1-pyrroline-2-carboxylate.

This existence of this pathway is supported by radio tracer experiments. No information is available about the enzymes or genes of this pathway in plants.

Citations: [Mestichelli79]

Variants: L-arginine degradation VI (arginase 2 pathway), L-ornithine degradation I (L-proline biosynthesis), L-proline biosynthesis I, L-proline biosynthesis II (from arginine), L-proline biosynthesis III


Mestichelli79: Mestichelli LJ, Gupta RN, Spenser ID (1979). "The biosynthetic route from ornithine to proline." J Biol Chem 254(3);640-7. PMID: 762087

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Watanabe14a: Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y (2014). "Identification and characterization of trans-3-hydroxy-l-proline dehydratase and Δ(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria." FEBS Open Bio 4;240-50. PMID: 24649405

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Sun Nov 29, 2015, BIOCYC13A.