This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Superclasses:||Degradation/Utilization/Assimilation → Aromatic Compounds Degradation → Sulfoaromatic Compounds Degradation → 4-Toluenesulfonate Degradation|
Some taxa known to possess this pathway include : Alcaligenes sp. O-1
Expected Taxonomic Range: Proteobacteria
Alcaligenes sp. O-1 can utilize three sulfonated aromatic compounds as sole sources of carbon and energy. 4-toluenesulfonate (TS) and benzenesulfonate (BS) are desulfonated by the same enzyme system, the benzenesulfonate dioxygenase system / 4-toluenesulfonate dioxygenase system (B/TSDOS). Another enzyme system, 2-aminobenzenesulfonate dioxygenase system / orthanilate dioxygenase system, can also desulfonate both TS and BS. The desulfonated products then undergo meta-ring cleavage reactions. The cleavage product of 4-methylcatechol is not shown as it is unknown whether a 1,6- or a 2,3-cleavage occurs [Junker94a, Cook98].
Variants: 4-toluenesulfonate degradation I
Relationship Links: Eawag-BBD-Pathways:PART-OF:tsa
Junker94a: Junker F, Leisinger T, Cook AM (1994). "3-Sulphocatechol 2,3-dioxygenase and other dioxygenases (EC 184.108.40.206 and EC 1.14.12.-) in the degradative pathways of 2-aminobenzenesulphonic, benzenesulphonic and 4-toluenesulphonic acids in Alcaligenes sp. strain O-1." Microbiology 1994;140 ( Pt 7);1713-22. PMID: 8075807
Junker94: Junker F, Field JA, Bangerter F, Ramsteiner K, Kohler HP, Joannou CL, Mason JR, Leisinger T, Cook AM (1994). "Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid." Biochem J 1994;300 ( Pt 2);429-36. PMID: 8002948
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