MetaCyc Pathway: 4-toluenesulfonate degradation II
Inferred from experiment

Pathway diagram: 4-toluenesulfonate degradation II

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: Degradation/Utilization/AssimilationAromatic Compounds DegradationSulfoaromatic Compounds Degradation4-Toluenesulfonate Degradation

Some taxa known to possess this pathway include : Alcaligenes sp. O-1

Expected Taxonomic Range: Proteobacteria

Alcaligenes sp. O-1 can utilize three sulfonated aromatic compounds as sole sources of carbon and energy. 4-toluenesulfonate (TS) and benzenesulfonate (BS) are desulfonated by the same enzyme system, the benzenesulfonate dioxygenase system / 4-toluenesulfonate dioxygenase system (B/TSDOS). Another enzyme system, 2-aminobenzenesulfonate dioxygenase system / orthanilate dioxygenase system, can also desulfonate both TS and BS. The desulfonated products then undergo meta-ring cleavage reactions. The cleavage product of 4-methylcatechol is not shown as it is unknown whether a 1,6- or a 2,3-cleavage occurs [Junker94a, Cook98].

Variants: 4-toluenesulfonate degradation I

Relationship Links: Eawag-BBD-Pathways:PART-OF:tsa

Created 04-May-2006 by Caspi R, SRI International


Cook98: Cook AM, Laue H, Junker F (1998). "Microbial desulfonation." FEMS Microbiol Rev 1998;22(5);399-419. PMID: 9990724

Junker94a: Junker F, Leisinger T, Cook AM (1994). "3-Sulphocatechol 2,3-dioxygenase and other dioxygenases (EC and EC 1.14.12.-) in the degradative pathways of 2-aminobenzenesulphonic, benzenesulphonic and 4-toluenesulphonic acids in Alcaligenes sp. strain O-1." Microbiology 1994;140 ( Pt 7);1713-22. PMID: 8075807

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Junker94: Junker F, Field JA, Bangerter F, Ramsteiner K, Kohler HP, Joannou CL, Mason JR, Leisinger T, Cook AM (1994). "Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid." Biochem J 1994;300 ( Pt 2);429-36. PMID: 8002948

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed Nov 25, 2015, biocyc12.