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MetaCyc Pathway: chrysin biosynthesis
Inferred from experiment

Pathway diagram: chrysin biosynthesis

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: BiosynthesisSecondary Metabolites BiosynthesisPhenylpropanoid Derivatives BiosynthesisFlavonoids BiosynthesisFlavonols Biosynthesis

Some taxa known to possess this pathway include : Petroselinum crispum

Expected Taxonomic Range: Apiaceae

Chrysin is an alternative product of reactions utilizing pinocembrin. Pinobanksin is also produced from pinocembrin. Intermediates prior to pinocembrin are equivalent for chrysin and pinobanksin, though they have been characterized in different organisms.

Created 03-Oct-2006 by Walk T, TAIR


Leonard05: Leonard E, Yan Y, Lim KH, Koffas MA (2005). "Investigation of two distinct flavone synthases for plant-specific flavone biosynthesis in Saccharomyces cerevisiae." Appl Environ Microbiol 71(12);8241-8. PMID: 16332809

Miyahisa05: Miyahisa I, Funa N, Ohnishi Y, Martens S, Moriguchi T, Horinouchi S (2005). "Combinatorial biosynthesis of flavones and flavonols in Escherichia coli." Appl Microbiol Biotechnol NIL;1-6. PMID: 16133333

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Akashi99a: Akashi T, Fukuchi-Mizutani M, Aoki T, Ueyama Y, Yonekura-Sakakibara K, Tanaka Y, Kusumi T, Ayabe S (1999). "Molecular cloning and biochemical characterization of a novel cytochrome P450, flavone synthase II, that catalyzes direct conversion of flavanones to flavones." Plant Cell Physiol 40(11);1182-6. PMID: 10635120

Baldwin88: Baldwin JE, Abraham E (1988). "The biosynthesis of penicillins and cephalosporins." Nat Prod Rep 5(2);129-45. PMID: 3145474

Britsch90: Britsch L (1990). "Purification and characterization of flavone synthase I, a 2-oxoglutarate-dependent desaturase." Arch Biochem Biophys 282(1);152-60. PMID: 2221917

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Martens01: Martens S, Forkmann G, Matern U, Lukacin R (2001). "Cloning of parsley flavone synthase I." Phytochemistry 58(1);43-6. PMID: 11524111

Martens99: Martens S, Forkmann G (1999). "Cloning and expression of flavone synthase II from Gerbera hybrids." Plant J 20(5);611-8. PMID: 10652133

Prescott96: Prescott AG, John P (1996). "DIOXYGENASES: Molecular Structure and Role in Plant Metabolism." Annu Rev Plant Physiol Plant Mol Biol 47;245-271. PMID: 15012289

Salowe90: Salowe SP, Marsh EN, Townsend CA (1990). "Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis." Biochemistry 29(27);6499-508. PMID: 2207091

Stenflo89: Stenflo J, Holme E, Lindstedt S, Chandramouli N, Huang LH, Tam JP, Merrifield RB (1989). "Hydroxylation of aspartic acid in domains homologous to the epidermal growth factor precursor is catalyzed by a 2-oxoglutarate-dependent dioxygenase." Proc Natl Acad Sci U S A 86(2);444-7. PMID: 2492106

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Mon May 2, 2016, biocyc13.