This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Superclasses:||Biosynthesis → Secondary Metabolites Biosynthesis → Phenylpropanoid Derivatives Biosynthesis → Flavonoids Biosynthesis → Flavonols Biosynthesis|
Some taxa known to possess this pathway include : Petroselinum crispum
Expected Taxonomic Range: Apiaceae
Chrysin is an alternative product of reactions utilizing pinocembrin. Pinobanksin is also produced from pinocembrin. Intermediates prior to pinocembrin are equivalent for chrysin and pinobanksin, though they have been characterized in different organisms.
Leonard05: Leonard E, Yan Y, Lim KH, Koffas MA (2005). "Investigation of two distinct flavone synthases for plant-specific flavone biosynthesis in Saccharomyces cerevisiae." Appl Environ Microbiol 71(12);8241-8. PMID: 16332809
Miyahisa05: Miyahisa I, Funa N, Ohnishi Y, Martens S, Moriguchi T, Horinouchi S (2005). "Combinatorial biosynthesis of flavones and flavonols in Escherichia coli." Appl Microbiol Biotechnol NIL;1-6. PMID: 16133333
Akashi99: Akashi T, Fukuchi-Mizutani M, Aoki T, Ueyama Y, Yonekura-Sakakibara K, Tanaka Y, Kusumi T, Ayabe S (1999). "Molecular cloning and biochemical characterization of a novel cytochrome P450, flavone synthase II, that catalyzes direct conversion of flavanones to flavones." Plant Cell Physiol 40(11);1182-6. PMID: 10635120
Salowe90: Salowe SP, Marsh EN, Townsend CA (1990). "Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis." Biochemistry 29(27);6499-508. PMID: 2207091
Stenflo89: Stenflo J, Holme E, Lindstedt S, Chandramouli N, Huang LH, Tam JP, Merrifield RB (1989). "Hydroxylation of aspartic acid in domains homologous to the epidermal growth factor precursor is catalyzed by a 2-oxoglutarate-dependent dioxygenase." Proc Natl Acad Sci U S A 86(2);444-7. PMID: 2492106
©2014 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493