This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
Synonyms: dimorphecolic acid biosynthesis
|Superclasses:||Biosynthesis → Fatty Acids and Lipids Biosynthesis → Fatty Acid Biosynthesis → Unusual Fatty Acid Biosynthesis → Conjugated Fatty Acid Biosynthesis|
Some taxa known to possess this pathway include : Dimorphotheca sinuata
Expected Taxonomic Range: Magnoliophyta
Dimorphecolate (9-OH-18:2Δ10trans,12trans) is the major seed fatty acid of Dimorphotheca species. It is a conjugated fatty acid and has three unusual structural features: 1) a C-9 hydroxyl group, 2) conjugated Δ10,Δ12 double bonds, and 3) a trans-Δ12 double bond. This special fatty acid has potential values in industrial applications such as in the manufacture of paints, inks, lubricants, plastics, and nylon.
Dimorphecolate is derived from oleic acid by the concerted activity of two divergent Δ12-oleic acid desaturases, FAD2-1 and FAD2-2. cDNAs of both enzymes have been cloned. Ectopic expression in yeast and soybean somatic embryo cells demonstrated that FAD2-1 encodes a trans-Δ12-oleic acid desaturase which is able to convert oleic acid (18:1Δ9cis) to trans-Δ12 linoleic acid (18:2Δ9cis,12trans). The ectopic expression experiments also demonstrated that FAD2-2 encodes a delta9 fatty acid conjugase-like enzyme which is able to convert the Δ9 double bond of linoleic acid into a C-9 hydroxyl group and a trans-Δ10 double bond.
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