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discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Pathway: dimorphecolate biosynthesis

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Synonyms: dimorphecolic acid biosynthesis

Superclasses: Biosynthesis Fatty Acids and Lipids Biosynthesis Fatty Acid Biosynthesis Unusual Fatty Acid Biosynthesis Conjugated Fatty Acid Biosynthesis

Some taxa known to possess this pathway include ? : Dimorphotheca sinuata

Expected Taxonomic Range: Magnoliophyta

Summary:
Dimorphecolate (9-OH-18:2Δ10trans,12trans) is the major seed fatty acid of Dimorphotheca species. It is a conjugated fatty acid and has three unusual structural features: 1) a C-9 hydroxyl group, 2) conjugated Δ10,Δ12 double bonds, and 3) a trans-Δ12 double bond. This special fatty acid has potential values in industrial applications such as in the manufacture of paints, inks, lubricants, plastics, and nylon.

Dimorphecolate is derived from oleic acid by the concerted activity of two divergent Δ12-oleic acid desaturases, FAD2-1 and FAD2-2. cDNAs of both enzymes have been cloned. Ectopic expression in yeast and soybean somatic embryo cells demonstrated that FAD2-1 encodes a trans-Δ12-oleic acid desaturase which is able to convert oleic acid (18:1Δ9cis) to trans-Δ12 linoleic acid (18:2Δ9cis,12trans). The ectopic expression experiments also demonstrated that FAD2-2 encodes a delta9 fatty acid conjugase-like enzyme which is able to convert the Δ9 double bond of linoleic acid into a C-9 hydroxyl group and a trans-Δ10 double bond.

Citations: [Cahoon04]

Credits:
Created 05-Oct-2006 by Zhang P , TAIR


References

Cahoon04: Cahoon EB, Kinney AJ (2004). "Dimorphecolic acid is synthesized by the coordinate activities of two divergent Delta12-oleic acid desaturases." J Biol Chem 279(13);12495-502. PMID: 14718523

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 18, 2014, BIOCYC13B.