This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Superclasses:||Biosynthesis → Secondary Metabolites Biosynthesis → Phenylpropanoid Derivatives Biosynthesis → Quinone Secondary Metabolites Biosynthesis|
Some taxa known to possess this pathway include : Setophoma sacchari
Expected Taxonomic Range: Eukaryota
Emodin appears to be produced from acetyl-CoA and malonyl-CoA [Zobayed06], though specifics of this biosynthesis have not been published. Emodin is an intermediate in secalonic acid production [Kurobane79, Zeng04], which has been isolated from fungi and implicated as a phytoxic substance that weakens plant defenses and increases susceptibility to fungal pathogens. Anthraquinones, such as chrysophanol and emodin, are also toxic substances found in a range of fungal and plant species [Anderson86, Mueller99a]. In plants, these compounds appear to function in defense [Shen02].
Anderson88d: Anderson JA, Lin BK, Williams HJ, Scott AI (1988). "Deoxygenation of phenolic natural products. Enzymatic conversion of emodin to chrysophanol." Journal of the American Chemical Society 110:1624-1626.
Kurobane79: Kurobane I, Vining LC, McInnes AG (1979). "Biosynthetic relationships among the secalonic acids. Isolation of emodin, endocrocin and secalonic acids from Pyrenochaeta terrestris and Aspergillus aculeatus." J Antibiot (Tokyo) 32(12);1256-66. PMID: 541252
Mueller99a: Mueller SO, Schmitt M, Dekant W, Stopper H, Schlatter J, Schreier P, Lutz WK (1999). "Occurrence of emodin, chrysophanol and physcion in vegetables, herbs and liquors. Genotoxicity and anti-genotoxicity of the anthraquinones and of the whole plants." Food Chem Toxicol 37(5);481-91. PMID: 10456676
Zobayed06: Zobayed SM, Afreen F, Goto E, Kozai T (2006). "Plant-Environment Interactions: Accumulation of Hypericin in Dark Glands of Hypericum perforatum." Ann Bot (Lond) 98(4);793-804. PMID: 16891333
©2016 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493