This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
Synonyms: calendic acid biosynthesis
|Superclasses:||Biosynthesis → Fatty Acid and Lipid Biosynthesis → Fatty Acid Biosynthesis → Unusual Fatty Acid Biosynthesis → Conjugated Fatty Acid Biosynthesis|
Some taxa known to possess this pathway include : Calendula officinalis
Expected Taxonomic Range: Magnoliophyta
Seed oils of a few plant species are enriched in conjugated fatty aids, which are fatty acids containing conjugated or non-methylene-interrupted double bonds. Because conjugated double bonds have high rates of oxidation, seed oils rich in conjugated double bonds are used commercially as drying agents in paints and varnishes.
The conjugated double bonds are introduced by "conjugases", divergent forms of FAD2 (EC 1.14.19.f, acyl-lipid ω-6 desaturase (cytochrome b5)). Conjugases act on fatty acids bound to phosphatidylcholine as substrates, as has been shown for FAD2 enzymes, and modify an existing double bond to produce the conjugated double bonds with or without introducing a new double bond.
Calendate ((8E,10E,12Z)-octadeca-8,10,12-trienoate) is a conjugated form of linoleate. It is a major fatty acid component of the seed oil of Calendula officinalis, an annual flowering plant in which calendate comprises more than 40% of the seed lipid fatty acids.
Cahoon01: Cahoon EB, Ripp KG, Hall SE, Kinney AJ (2001). "Formation of conjugated delta8,delta10-double bonds by delta12-oleic-acid desaturase-related enzymes: biosynthetic origin of calendic acid." J Biol Chem 276(4);2637-43. PMID: 11067856
Qiu01: Qiu X, Reed DW, Hong H, MacKenzie SL, Covello PS (2001). "Identification and analysis of a gene from Calendula officinalis encoding a fatty acid conjugase." Plant Physiol 125(2);847-55. PMID: 11161042
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