This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Superclasses:||Biosynthesis → Fatty Acids and Lipids Biosynthesis → Fatty Acid Biosynthesis → Unusual Fatty Acid Biosynthesis → Conjugated Fatty Acid Biosynthesis|
Expected Taxonomic Range: Magnoliophyta
Seed oils of a few plant species are enriched in conjugated fatty aids, fatty acids containing conjugated or non-methylene-interrupted double bonds. These conjugated double bonds are introduced by "conjugases", divergent forms of FAD2 (oleic acid desaturase). Conjugases modify an existing double bond to produce the conjugated double bonds with or without introducing a new double bond. They use fatty acids bound to phosphatidylcholine as substrates, as has been shown for FAD2 enzymes. Because conjugated double bonds have high rates of oxidation, seed oils rich in conjugated double bonds are used commercially as drying agents in paints and varnishes.
α-eleostearic acid (18:3Δ9cis,11trans,13trans) is a conjugated form of linolenic acid (18:3Δ9cis,12cis,15cis). It accounts for 80% (w/w) of tung oil. α-eleostearic acid is derived from linoleic acid (18:2Δ9cis,12cis) by a fatty acid conjugase which converts a cis Δ12 double bond into a conjugated trans-trans double bond system.
Cahoon99: Cahoon EB, Carlson TJ, Ripp KG, Schweiger BJ, Cook GA, Hall SE, Kinney AJ (1999). "Biosynthetic origin of conjugated double bonds: production of fatty acid components of high-value drying oils in transgenic soybean embryos." Proc Natl Acad Sci U S A 96(22);12935-40. PMID: 10536026
Dyer02: Dyer JM, Chapital DC, Kuan JC, Mullen RT, Turner C, McKeon TA, Pepperman AB (2002). "Molecular analysis of a bifunctional fatty acid conjugase/desaturase from tung. Implications for the evolution of plant fatty acid diversity." Plant Physiol 130(4);2027-38. PMID: 12481086
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