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discounted EARLY registration ends Dec 31, 2014
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Pathway: nitrobenzene degradation II

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: Degradation/Utilization/Assimilation Aromatic Compounds Degradation Nitroaromatic Compounds Degradation Nitrobenzene Degradation

Some taxa known to possess this pathway include ? : Comamonas sp. JS765

Expected Taxonomic Range: Bacteria

Summary:
nitrobenzene is frequently released in the effluent from explosives manufacture as well as in the manufacture of organic chemicals and plastics. It is the primary starting material for the manufacture of aniline, a compound used in the production of polyurethane [Nishino93]. The pollution potential of nitrobenzene is very large, and it is listed among the U.S. Environmental Protection Agency priority pollutants [Callahan79].

The bacterium Comamonas sp. JS765, which was isolated from an industrial waste treatment plant in New Jersey, can utilize nitrobenzene as the sole source for carbon, nitrogen and energy [Nishino95]. nitrobenzene is converted to catechol by the enzyme nitrobenzene dioxygenase, a large complex that belongs to the family of Rieske nonheme iron oxygenases [Lessner02]. The catechol is then degraded by a meta-cleavage pathway via 2-oxopent-4-enoate to pyruvate and acetyl-CoA [He99].

A different pathway for the degeradation of nitrobenzene is described in nitrobenzene degradation I.

Variants: 4-chloronitrobenzene degradation , nitrobenzene degradation I

Relationship Links: Eawag-BBD-Pathways:PART-OF:nb

Credits:
Created 27-Aug-2007 by Caspi R , SRI International


References

Callahan79: Callahan, M. A., Slimak, M. W., Gabel, N. W., May, J. P., Fowler, C. F., Freed, J. R., Jennings, P., Durfee, R. L., Whitmore, F. C., Maestri, B., Mabey, W. R., Holt, B. R., Gould, C. (1979). "Water-related environmental fate of 129 priority pollutants." EPA report-440/4-79-029b. U.S. Environmental Protection Agency, Washington, D.C.

He99: He Z, Spain JC (1999). "Comparison of the downstream pathways for degradation of nitrobenzene by Pseudomonas pseudoalcaligenes JS45 (2-aminophenol pathway) and by Comamonas sp. JS765 (catechol pathway)." Arch Microbiol 171(5);309-16. PMID: 10382261

Lessner02: Lessner DJ, Johnson GR, Parales RE, Spain JC, Gibson DT (2002). "Molecular characterization and substrate specificity of nitrobenzene dioxygenase from Comamonas sp. strain JS765." Appl Environ Microbiol 68(2);634-41. PMID: 11823201

Nishino93: Nishino SF, Spain JC (1993). "Degradation of nitrobenzene by a Pseudomonas pseudoalcaligenes." Appl Environ Microbiol 59(8);2520-5. PMID: 8368838

Nishino95: Nishino SF, Spain JC (1995). "Oxidative Pathway for the Biodegradation of Nitrobenzene by Comamonas sp. Strain JS765." Appl Environ Microbiol 61(6);2308-2313. PMID: 16535050

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Parales05: Parales RE, Huang R, Yu CL, Parales JV, Lee FK, Lessner DJ, Ivkovic-Jensen MM, Liu W, Friemann R, Ramaswamy S, Gibson DT (2005). "Purification, characterization, and crystallization of the components of the nitrobenzene and 2-nitrotoluene dioxygenase enzyme systems." Appl Environ Microbiol 71(7);3806-14. PMID: 16000792


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, biocyc14.