This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Superclasses:||Biosynthesis → Fatty Acids and Lipids Biosynthesis → Phospholipid Biosynthesis → Cardiolipin Biosynthesis|
Some taxa known to possess this pathway include : Escherichia coli K-12 substr. MG1655
Expected Taxonomic Range:
a cardiolipin is an anionic membrane phospholipid. Along with phosphatidylglycerol, the anionic lipids are important for the biogenesis and function of membranes. Cardiolipin is present in the plasma membrane of bacteria and in the mitochondrial membrane in eukaryotes.
A main difference exists between bacterial and eukaryotic cardiolipin biosynthesis; In bacteria cardiolipin is formed by the condensation of two molecules of an L-1-phosphatidyl-glycerol, while in eukaryotes it is formed from one molecule of a CDP-diacylglycerol and one molecule of an L-1-phosphatidyl-glycerol.
Superpathways: phospholipid biosynthesis I
Unification Links: EcoCyc:PWY-5668
Baba06: Baba T, Ara T, Hasegawa M, Takai Y, Okumura Y, Baba M, Datsenko KA, Tomita M, Wanner BL, Mori H (2006). "Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection." Mol Syst Biol 2;2006.0008. PMID: 16738554
Babu11a: Babu M, Diaz-Mejia JJ, Vlasblom J, Gagarinova A, Phanse S, Graham C, Yousif F, Ding H, Xiong X, Nazarians-Armavil A, Alamgir M, Ali M, Pogoutse O, Pe'er A, Arnold R, Michaut M, Parkinson J, Golshani A, Whitfield C, Wodak SJ, Moreno-Hagelsieb G, Greenblatt JF, Emili A (2011). "Genetic interaction maps in Escherichia coli reveal functional crosstalk among cell envelope biogenesis pathways." PLoS Genet 7(11);e1002377. PMID: 22125496
DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114
Dillon96: Dillon DA, Wu WI, Riedel B, Wissing JB, Dowhan W, Carman GM (1996). "The Escherichia coli pgpB gene encodes for a diacylglycerol pyrophosphate phosphatase activity." J Biol Chem 271(48);30548-53. PMID: 8940025
El05: El Ghachi M, Derbise A, Bouhss A, Mengin-Lecreulx D (2005). "Identification of multiple genes encoding membrane proteins with undecaprenyl pyrophosphate phosphatase (UppP) activity in Escherichia coli." J Biol Chem 280(19);18689-95. PMID: 15778224
Funk92: Funk CR, Zimniak L, Dowhan W (1992). "The pgpA and pgpB genes of Escherichia coli are not essential: evidence for a third phosphatidylglycerophosphate phosphatase." J Bacteriol 1992;174(1);205-13. PMID: 1309518
Gopalakrishnan86: Gopalakrishnan AS, Chen YC, Temkin M, Dowhan W (1986). "Structure and expression of the gene locus encoding the phosphatidylglycerophosphate synthase of Escherichia coli." J Biol Chem 1986;261(3);1329-38. PMID: 3003065
Griebau94: Griebau R, Frentzen M (1994). "Biosynthesis of Phosphatidylglycerol in Isolated Mitochondria of Etiolated Mung Bean (Vigna radiata L.) Seedlings." Plant Physiol 105(4);1269-1274. PMID: 12232283
Hirabayashi76: Hirabayashi T, Larson TJ, Dowhan W (1976). "Membrane-associated phosphatidylglycerophosphate synthetase from Escherichia coli: purification by substrate affinity chromatography on cytidine 5'-diphospho-1,2-diacyl-sn-glycerol sepharose." Biochemistry 1976;15(24);5205-11. PMID: 793612
Hiraoka91: Hiraoka S, Nukui K, Uetake N, Ohta A, Shibuya I (1991). "Amplification and substantial purification of cardiolipin synthase of Escherichia coli." J Biochem (Tokyo) 1991;110(3);443-9. PMID: 1663113
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