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MetaCyc Pathway: cardiolipin biosynthesis I
Inferred from experiment

Pathway diagram: cardiolipin biosynthesis I

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: BiosynthesisFatty Acid and Lipid BiosynthesisPhospholipid BiosynthesisCardiolipin Biosynthesis

Some taxa known to possess this pathway include : Escherichia coli K-12 substr. MG1655

Expected Taxonomic Range: Bacteria

a cardiolipin is an anionic membrane phospholipid. Along with phosphatidylglycerol, the anionic lipids are important for the biogenesis and function of membranes. Cardiolipin is present in the plasma membrane of bacteria and in the mitochondrial membrane in eukaryotes.

A main difference exists between bacterial and eukaryotic cardiolipin biosynthesis; In bacteria cardiolipin is formed by the condensation of two molecules of an L-1-phosphatidyl-glycerol, while in eukaryotes it is formed from one molecule of a CDP-diacylglycerol and one molecule of an L-1-phosphatidyl-glycerol.

Superpathways: superpathway of phospholipid biosynthesis I (bacteria)

Variants: cardiolipin and phosphatidylethanolamine biosynthesis (Xanthomonas), cardiolipin biosynthesis II, cardiolipin biosynthesis III

Unification Links: EcoCyc:PWY-5668

Created 10-Oct-2007 by Caspi R, SRI International

References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Baba06: Baba T, Ara T, Hasegawa M, Takai Y, Okumura Y, Baba M, Datsenko KA, Tomita M, Wanner BL, Mori H (2006). "Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection." Mol Syst Biol 2;2006.0008. PMID: 16738554

Babu11a: Babu M, Diaz-Mejia JJ, Vlasblom J, Gagarinova A, Phanse S, Graham C, Yousif F, Ding H, Xiong X, Nazarians-Armavil A, Alamgir M, Ali M, Pogoutse O, Pe'er A, Arnold R, Michaut M, Parkinson J, Golshani A, Whitfield C, Wodak SJ, Moreno-Hagelsieb G, Greenblatt JF, Emili A (2011). "Genetic interaction maps in Escherichia coli reveal functional crosstalk among cell envelope biogenesis pathways." PLoS Genet 7(11);e1002377. PMID: 22125496

BRENDA14: BRENDA team (2014). Imported from BRENDA version existing on Aug 2014.

Chang67: Chang YY, Kennedy EP (1967). "Phosphatidyl glycerophosphate phosphatase." J Lipid Res 8(5);456-62. PMID: 4292860

Daley05: Daley DO, Rapp M, Granseth E, Melen K, Drew D, von Heijne G (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308(5726);1321-3. PMID: 15919996

DiazMejia09: Diaz-Mejia JJ, Babu M, Emili A (2009). "Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome." FEMS Microbiol Rev 33(1);66-97. PMID: 19054114

Dillon96: Dillon DA, Wu WI, Riedel B, Wissing JB, Dowhan W, Carman GM (1996). "The Escherichia coli pgpB gene encodes for a diacylglycerol pyrophosphate phosphatase activity." J Biol Chem 271(48);30548-53. PMID: 8940025

Dowhan92: Dowhan W (1992). "Phosphatidylglycerophosphate synthase from Escherichia coli." Methods Enzymol 1992;209;313-21. PMID: 1323047

Dowhan92a: Dowhan W, Funk CR (1992). "Phosphatidylglycerophosphate phosphatase from Escherichia coli." Methods Enzymol 209;224-30. PMID: 1323035

El05: El Ghachi M, Derbise A, Bouhss A, Mengin-Lecreulx D (2005). "Identification of multiple genes encoding membrane proteins with undecaprenyl pyrophosphate phosphatase (UppP) activity in Escherichia coli." J Biol Chem 280(19);18689-95. PMID: 15778224

Funk92: Funk CR, Zimniak L, Dowhan W (1992). "The pgpA and pgpB genes of Escherichia coli are not essential: evidence for a third phosphatidylglycerophosphate phosphatase." J Bacteriol 1992;174(1);205-13. PMID: 1309518

Gaudet10: Gaudet P, Livstone M, Thomas P (2010). "Annotation inferences using phylogenetic trees." PMID: 19578431

GOA01: GOA, MGI (2001). "Gene Ontology annotation based on Enzyme Commission mapping." Genomics 74;121-128.

GOA01a: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."

GOA06: GOA, SIB (2006). "Electronic Gene Ontology annotations created by transferring manual GO annotations between orthologous microbial proteins."

Gopalakrishnan86: Gopalakrishnan AS, Chen YC, Temkin M, Dowhan W (1986). "Structure and expression of the gene locus encoding the phosphatidylglycerophosphate synthase of Escherichia coli." J Biol Chem 1986;261(3);1329-38. PMID: 3003065

Griebau94: Griebau R, Frentzen M (1994). "Biosynthesis of Phosphatidylglycerol in Isolated Mitochondria of Etiolated Mung Bean (Vigna radiata L.) Seedlings." Plant Physiol 105(4);1269-1274. PMID: 12232283

Guo00: Guo D, Tropp BE (2000). "A second Escherichia coli protein with CL synthase activity." Biochim Biophys Acta 1483(2);263-74. PMID: 10634942

Heber91: Heber S, Tropp BE (1991). "Genetic regulation of cardiolipin synthase in Escherichia coli." Biochim Biophys Acta 1129(1);1-12. PMID: 1661609

Hirabayashi76: Hirabayashi T, Larson TJ, Dowhan W (1976). "Membrane-associated phosphatidylglycerophosphate synthetase from Escherichia coli: purification by substrate affinity chromatography on cytidine 5'-diphospho-1,2-diacyl-sn-glycerol sepharose." Biochemistry 1976;15(24);5205-11. PMID: 793612

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed May 4, 2016, biocyc14.