This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Superclasses:||Biosynthesis → Cofactors, Prosthetic Groups, Electron Carriers Biosynthesis → Polyprenyl Biosynthesis|
Some taxa known to possess this pathway include : Agromyces mediolanus, Bacteroides eggerthii, Bacteroides fragilis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus, Leifsonia aquatica, Microbacterium barkeri, Microbacterium imperiale, Microbacterium lacticum, Microbacterium liquefaciens, Microbacterium saperdae, Microbacterium testaceum, Prevotella brevis, Prevotella intermedia, Prevotella oralis, Prevotella ruminicola
In this pathway multiple units of isopentenyl diphosphate (IPP) undergo a series of polymerizations to form a polyisoprenoid chain of 11 prenyl units in trans form. This product should not be confused with di-trans,octa-cis-undecaprenyl diphosphate, which serves an entirely different role in the cell, and whose biosynthesis is described in di-trans,poly-cis-undecaprenyl phosphate biosynthesis.
Additional isoprenoid units are added to a maximal length that is determined by the specific enzyme. Most organisms generate polyprenyl chains of predominantly one length. Once completed, the polyprenyl chain is incorporated into other molecules, such as quinones. The enzyme that attaches the polyprenyl chain to the quinone precursor molecule does not have a preference towards a particular length. Thus, the length of the polyprenyl chain in the mature quinone molecule is determined by the predominant polyprenyl diphosphate synthase enzyme of the organism.
In most organisms there is one type of a predominant quinone, with a specific polyprenyl chain length. However, most organisms also have minor amounts of quinones with a different polyprenyl chain length. For a review detailing the polyprenyl chain length in different bacteria, see [Collins81].
Superpathways: superpathway of menaquinol-11 biosynthesis
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