Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Pathway: trichloroethylene degradation

Enzyme View:

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: Degradation/Utilization/Assimilation Chlorinated Compounds Degradation

Some taxa known to possess this pathway include ? : Atropa belladonna , Nicotiana tabacum , Populus trichocarpa

Expected Taxonomic Range: Viridiplantae

Summary:
Trichloroethylene (TCE) is one of the most common industrial pollutants. It has been used widely as degreaser, drycleaning agent and as anesthetic. TCE is a mutagen and suspected corcinogen [Moore00]. Its wide spread prevalence and limited biodegradability posses a difficult and expensive remidiation. Phytoremidiation has been studied as an alternative and effective way to remove TCE. Several plants have been shown to be capable of taking up and metabolizing TCE [Gordon98] [Graber07][Doty07].

Credits:
Created 27-Feb-2008 by Karthikeyan AS , TAIR


References

Doty07: Doty SL, James CA, Moore AL, Vajzovic A, Singleton GL, Ma C, Khan Z, Xin G, Kang JW, Park JY, Meilan R, Strauss SH, Wilkerson J, Farin F, Strand SE (2007). "Enhanced phytoremediation of volatile environmental pollutants with transgenic trees." Proc Natl Acad Sci U S A 104(43);16816-21. PMID: 17940038

Gordon98: Gordon M, Choe N, Duffy J, Ekuan G, Heilman P, Muiznieks I, Ruszaj M, Shurtleff BB, Strand S, Wilmoth J, Newman LA (1998). "Phytoremediation of trichloroethylene with hybrid poplars." Environ Health Perspect 106 Suppl 4;1001-4. PMID: 9703485

Graber07: Graber ER, Sorek A, Tsechansky L, Atzmon N (2007). "Competitive uptake of trichloroethene and 1,1,1-trichloroethane by Eucalyptus camaldulensis seedlings and wood." Environ Sci Technol 41(19);6704-10. PMID: 17969684

Moore00: Moore MM, Harrington-Brock K (2000). "Mutagenicity of trichloroethylene and its metabolites: implications for the risk assessment of trichloroethylene." Environ Health Perspect 108 Suppl 2;215-23. PMID: 10807553

Shang01: Shang TQ, Doty SL, Wilson AM, Howald WN, Gordon MP (2001). "Trichloroethylene oxidative metabolism in plants: the trichloroethanol pathway." Phytochemistry 58(7);1055-65. PMID: 11730869

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lazarowski03: Lazarowski ER, Shea DA, Boucher RC, Harden TK (2003). "Release of cellular UDP-glucose as a potential extracellular signaling molecule." Mol Pharmacol 63(5);1190-7. PMID: 12695547


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC13B.