This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Superclasses:||Biosynthesis → Aromatic Compounds Biosynthesis|
The conversion of L-tyrosine to 4-hydroxyphenylpyruvate by an aminotransferase is a common reaction, found in most organisms. In some organisms it is part of degradative pathways (as in L-tyrosine degradation I) while in others it is part of biosynthetic pathways (as in plastoquinol-9 biosynthesis I).
4-hydroxyphenylpyruvate is an central precursor, which is used for the synthesis of primary metabolites such as plastoquinone-9 and vitamin E, both important quinones found in all oxygenic photosynthetic organisms, as well as secondary metabolites, such as rosmarinate.
Superpathways: superpathway of plastoquinol biosynthesis
Cahoon03: Cahoon EB, Hall SE, Ripp KG, Ganzke TS, Hitz WD, Coughlan SJ (2003). "Metabolic redesign of vitamin E biosynthesis in plants for tocotrienol production and increased antioxidant content." Nat Biotechnol 21(9);1082-7. PMID: 12897790
Horvath: Horvath G, Wessjohann L, Bigirimana J, Monica H, Jansen M, Guisez Y, Caubergs R, Horemans N "Accumulation of tocopherols and tocotrienols during seed development of grape (Vitis vinifera L. cv. Albert Lavallee)." Plant Physiol Biochem 44(11-12);724-31. PMID: 17110122
AriasBarrau04: Arias-Barrau E, Olivera ER, Luengo JM, Fernandez C, Galan B, Garcia JL, Diaz E, Minambres B (2004). "The homogentisate pathway: a central catabolic pathway involved in the degradation of L-phenylalanine, L-tyrosine, and 3-hydroxyphenylacetate in Pseudomonas putida." J Bacteriol 186(15);5062-77. PMID: 15262943
Collier72: Collier RH, Kohlhaw G (1972). "Nonidentity of the aspartate and the aromatic aminotransferase components of transaminase A in Escherichia coli." J Bacteriol 1972;112(1);365-71. PMID: 4404056
DeEknamkul87a: De-Eknamkul W, Ellis BE (1987). "Purification and characterization of tyrosine aminotransferase activities from Anchusa officinalis cell cultures." Arch Biochem Biophys 257(2);430-8. PMID: 2889425
Dietrich91: Dietrich JB, Lorber B, Kern D (1991). "Expression of mammalian tyrosine aminotransferase in Saccharomyces cerevisiae and Escherichia coli. Purification to homogeneity and characterization of the enzyme overproduced in the bacteria." Eur J Biochem 201(2);399-407. PMID: 1682148
Editors93: "Bacillus subtilis and Other Gram-Positive Bacteria: Biochemistry, Physiology, and Molecular Genetics." (1993). Editors: Sonenshein, A.L., Hoch, J.A., Losick, R. American Society For Microbiology, Washington, DC.
Gu98: Gu W, Song J, Bonner CA, Xie G, Jensen RA (1998). "PhhC is an essential aminotransferase for aromatic amino acid catabolism in Pseudomonas aeruginosa." Microbiology 144 ( Pt 11);3127-34. PMID: 9846749
Natt92: Natt E, Kida K, Odievre M, Di Rocco M, Scherer G (1992). "Point mutations in the tyrosine aminotransferase gene in tyrosinemia type II." Proc Natl Acad Sci U S A 89(19);9297-301. PMID: 1357662
Ohisalo82: Ohisalo JJ, Laskowska-Klita T, Andersson SM (1982). "Development of tyrosine aminotransferase and para-hydroxyphenylpyruvate dioxygenase activities in fetal and neonatal human liver." J Clin Invest 70(1);198-200. PMID: 6123525
Powell78: Powell JT, Morrison JF (1978). "The purification and properties of the aspartate aminotransferase and aromatic-amino-acid aminotransferase from Escherichia coli." Eur J Biochem 1978;87(2);391-400. PMID: 352693
Schneider08: Schneider P, Bouhired S, Hoffmeister D (2008). "Characterization of the atromentin biosynthesis genes and enzymes in the homobasidiomycete Tapinella panuoides." Fungal Genet Biol 45(11);1487-96. PMID: 18805498
Stepanova08: Stepanova AN, Robertson-Hoyt J, Yun J, Benavente LM, Xie DY, Dolezal K, Schlereth A, Jurgens G, Alonso JM (2008). "TAA1-mediated auxin biosynthesis is essential for hormone crosstalk and plant development." Cell 133(1);177-91. PMID: 18394997
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