This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
Synonyms: GDP-L-fucose biosynthesis (salvage pathway)
|Superclasses:||Biosynthesis → Carbohydrates Biosynthesis → Sugars Biosynthesis → Sugar Nucleotides Biosynthesis → GDP-sugar Biosynthesis|
Expected Taxonomic Range: Eukaryota
L-Fucose is an important monosaccharide found in a diverse array of organisms. It is a carbohydrate component of bacterial lipopolysaccharides, mammalian and plant glycoproteins (such as the human antigenic glycoproteins or glycolipids of erythrocyte membranes) and various plant cell wall polysaccharides. It is found in xyloglucans and rhamnogalacturonans I and II. Fucosylation is performed by fucosyltransferases which require the activated form GDP-L-fucose (GDP-Fuc) as the donor substrate.
The formation of UDP-Fuc occurs via two routes: a) a salvage pathway leading to the formation of UDP-Fuc from free L-fucose (this pathway), and b) a de novo synthesis route from GDP-D-mannose (GDP-L-fucose biosynthesis I (from GDP-D-mannose)).
In plants, biosynthesis of GDP-L-fucose is thought to occur mainly through de novo synthesis. The primary role of the sugar salvage pathways is presumed to be in the recycling of sugars derived from the turnover of macromolecules such as polysaccharides, galactolipids and proteoglycans, which have sugar components. Although the presence of GDP-L-fucose pyrophosphorylase activity in sycamore cell cultures and corn roots has been suggested [Roberts68, Green78] no enzyme of this pathway have yet been described in plants.
Unification Links: AraCyc:PWY-6
Feingold82: Feingold D.S. (1982). "Aldo (and keto) hexoses and uronic acids." Plant Carbohydrates I - Intracellular carbohydrates, Encyclopedia of Plant Physiology, Vol 13A, Eds Loewus and Tanner, pp3-76.
Green78: Green JR, Northcote DH (1978). "The structure and function of glycoproteins synthesized during slime-polysaccharide production by membranes of the root-cap cells of maize (Zea mays)." Biochem J 170(3);599-608. PMID: 646802
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