This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Superclasses:||Biosynthesis → Fatty Acids and Lipids Biosynthesis → Sterol Biosynthesis|
Expected Taxonomic Range: Digitalis
Digitalis is a plant genus that belong to the Plantaginaceae and comprises several therapeutic species. Plants of the genus Digitalis produce cardiac glycosides [Gavidia07]. Cardenolides represent products of pharmaceutical value and possess a very complex basic skeleton of genin. It is widely accepted that the biosynthesis of cardenolides is connected to morphological differentiation, because the cardenolide content could be increased in the tissue after onset of differentiation [Berglund92] [Hirotani77], [Grave80]. Digitalis cardenolides are characterized by a steroid nucleus with rings connected cis-trans-cis' it has a 14beta-hydroxy group and an unsaturated five membered lactone ring is subsitituted at C-17beta.
Gavidia07: Gavidia I, Tarrio R, Rodriguez-Trelles F, Perez-Bermudez P, Seitz HU (2007). "Plant progesterone 5beta-reductase is not homologous to the animal enzyme. Molecular evolutionary characterization of P5betaR from Digitalis purpurea." Phytochemistry 68(6);853-64. PMID: 17184799
Bauer10: Bauer P, Munkert J, Brydziun M, Burda E, Muller-Uri F, Groger H, Muller YA, Kreis W (2010). "Highly conserved progesterone 5 beta-reductase genes (P5 beta R) from 5 beta-cardenolide-free and 5 beta-cardenolide-producing angiosperms." Phytochemistry 71(13);1495-505. PMID: 20598327
Herl06: Herl V, Fischer G, Muller-Uri F, Kreis W (2006). "Molecular cloning and heterologous expression of progesterone 5beta-reductase from Digitalis lanata Ehrh." Phytochemistry 67(3);225-31. PMID: 16386278
Herl09: Herl V, Fischer G, Reva VA, Stiebritz M, Muller YA, Muller-Uri F, Kreis W (2009). "The VEP1 gene (At4g24220) encodes a short-chain dehydrogenase/reductase with 3-oxo-Delta4,5-steroid 5beta-reductase activity in Arabidopsis thaliana L." Biochimie 91(4);517-25. PMID: 19166903
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