MetaCyc Pathway: dammara-20,24-diene biosynthesis
Inferred from experiment

Pathway diagram: dammara-20,24-diene biosynthesis

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Synonyms: tetracyclic triterpene hydrocarbon biosynthesis, dammara-18(28),21-diene biosynthesis

Superclasses: BiosynthesisSecondary Metabolites BiosynthesisTerpenoids BiosynthesisTriterpenoids Biosynthesis

Some taxa known to possess this pathway include : Dryopteris crassirhizoma

Expected Taxonomic Range: cellular organisms

Several kinds of cyclic triterpene hydrocarbons are produced by ferns. The key enzyme that is responsible for the biosynthesis of triterpenes are squalene synthases. Dryopteris crassirhizoma, leaflets shows the presence of dammara-20,24-dien (DCD). The enzyme squalene cyclase (SC) that produces this product has been cloned and the DCD represents the first SC that produces a tetracyclic triterpene hydrocarbon [Shinozaki08a].

Created 14-Nov-2008 by Pujar A, Boyce Thompson Institute


Shinozaki08: Shinozaki J, Shibuya M, Masuda K, Ebizuka Y (2008). "Squalene cyclase and oxidosqualene cyclase from a fern." FEBS Lett 582(2);310-8. PMID: 18154734

Shinozaki08a: Shinozaki J, Shibuya M, Masuda K, Ebizuka Y (2008). "Dammaradiene synthase, a squalene cyclase, from Dryopteris crassirhizoma Nakai." Phytochemistry 69(14);2559-64. PMID: 18790509

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed Nov 25, 2015, biocyc13.