This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
Synonyms: sucrose mobilization
|Superclasses:||Degradation/Utilization/Assimilation → Carbohydrates Degradation → Sugars Degradation → Sucrose Degradation|
In this pathway sucrose is cleaved by invertase ( EC 220.127.116.11, β-fructofuranosidase). This enzyme acts on β-D-fructofuranosides, releasing β-D-fructofuranose. When acting on sucrose, the products are β-D-fructofuranose and D-glucopyranose.
Invertases were studied extensively in yeast [Neumann67, BACON54], from which the enzyme was originally isolated in 1860 [Berthelot60]. However, invertase activity is very common in plants and other organisms.
The plant invertase activity is found in the cytoplasm, vacuole, and apoplast [Dey97a].
The hexoses generated by invertase are used to meet the energy and substrate requirements of the organism for growth, storage, or energy production.
Variants: sucrose degradation I (sucrose phosphotransferase), sucrose degradation II (sucrose synthase), sucrose degradation IV (sucrose phosphorylase), sucrose degradation V (sucrose α-glucosidase), sucrose degradation VII (sucrose 3-dehydrogenase), superpathway of anaerobic sucrose degradation
Unification Links: AraCyc:PWY-621
Ciereszko01: Ciereszko I, Johansson H, Hurry V, Kleczkowski LA (2001). "Phosphate status affects the gene expression, protein content and enzymatic activity of UDP-glucose pyrophosphorylase in wild-type and pho mutants of Arabidopsis." Planta 2001;212(4);598-605. PMID: 11525517
Martin93a: Martin T, Frommer WB, Salanoubat M, Willmitzer L (1993). "Expression of an Arabidopsis sucrose synthase gene indicates a role in metabolization of sucrose both during phloem loading and in sink organs." Plant J 1993;4(2);367-77. PMID: 8220487
Barratt09: Barratt DH, Derbyshire P, Findlay K, Pike M, Wellner N, Lunn J, Feil R, Simpson C, Maule AJ, Smith AM (2009). "Normal growth of Arabidopsis requires cytosolic invertase but not sucrose synthase." Proc Natl Acad Sci U S A 106(31);13124-9. PMID: 19470642
Baveja86: Baveja UK, Jyoti AS, Kaur M, Agarwal DS, Anand BS, Nanda R (1986). "Isoenzyme studies of Giardia lamblia isolated from symptomatic cases." Aust J Exp Biol Med Sci 64 ( Pt 2);119-26. PMID: 2943257
Bertrand76: Bertrand O, Kahn A, Cottreau D, Boivin P (1976). "Human leukocyte glucose-phosphate-isomerase purification by affinity elution and immunological study." Biochimie 58(3);261-7. PMID: 819039
But12: But SY, Rozova ON, Khmelenina VN, Reshetnikov AS, Trotsenko YA (2012). "Properties of recombinant ATP-dependent fructokinase from the halotolerant methanotroph Methylomicrobium alcaliphilum 20Z." Biochemistry (Mosc) 77(4);372-7. PMID: 22809156
But13: But SY, Khmelenina VN, Reshetnikov AS, Trotsenko YA (2013). "Bifunctional sucrose phosphate synthase/phosphatase is involved in the sucrose biosynthesis by Methylobacillus flagellatus KT." FEMS Microbiol Lett. PMID: 23865613
But13a: But SIu, Khmelina VN, Mustakhimova II, Trotsenko IuA (2013). "[Production and characterization of Methylomicrobium alcaliphilum 20Z knockout mutants, which has sucrose and ectoin synthesis defective genes]." Mikrobiologiia 82(2);251-3. PMID: 23808151
But15: But SY, Khmelenina VN, Reshetnikov AS, Mustakhimov II, Kalyuzhnaya MG, Trotsenko YA (2015). "Sucrose metabolism in halotolerant methanotroph Methylomicrobium alcaliphilum 20Z." Arch Microbiol. PMID: 25577257
Caescu04: Caescu CI, Vidal O, Krzewinski F, Artenie V, Bouquelet S (2004). "Bifidobacterium longum requires a fructokinase (Frk; ATP:D-fructose 6-phosphotransferase, EC 18.104.22.168) for fructose catabolism." J Bacteriol 186(19);6515-25. PMID: 15375133
Charng94: Charng YY, Juang RH, Su JC, Sung HY (1994). "Partial purification and characterization of invertase isozymes from rice grains (Oryza sativa)." Biochem Mol Biol Int 1994;33(3);607-15. PMID: 7951078
Conklin75: Conklin KA, Yamashiro KM, Gray GM (1975). "Human intestinal sucrase-isomaltase. Identification of free sucrase and isomaltase and cleavage of the hybrid into active distinct subunits." J Biol Chem 250(15);5735-41. PMID: 807575
Curtis75: Curtis SJ, Epstein W (1975). "Phosphorylation of D-glucose in Escherichia coli mutants defective in glucosephosphotransferase, mannosephosphotransferase, and glucokinase." J Bacteriol 122(3);1189-99. PMID: 1097393
Dai99: Dai N, Schaffer A, Petreikov M, Shahak Y, Giller Y, Ratner K, Levine A, Granot D (1999). "Overexpression of Arabidopsis hexokinase in tomato plants inhibits growth, reduces photosynthesis, and induces rapid senescence." Plant Cell 11(7);1253-66. PMID: 10402427
Doronina03: Doronina N, Darmaeva T, Trotsenko Y (2003). "Methylophaga natronica sp. nov., a new alkaliphilic and moderately halophilic, restricted-facultatively methylotrophic bacterium from soda lake of the Southern Transbaikal region." Syst Appl Microbiol 26(3);382-9. PMID: 14529181
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