This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Superclasses:||Biosynthesis → Secondary Metabolites Biosynthesis → Terpenoids Biosynthesis → Sesquiterpenoids Biosynthesis|
Some taxa known to possess this pathway include : Pogostemon cablin
Expected Taxonomic Range: Viridiplantae
The essential oil occurring in the patchouli (Pogostemon cablin) plant is stored in special glands of the leaves. There it accumulates large amounts of its main component (-)-patchoulol that can be extracted by steam distillation [Deguerry06]. The pleasant fragrances in this oil make it an important ingredient in commercial production of cosmetic products [Weyerstahl89] [Frater98]. The oil composition is complex and the main constituents are sesquiterpenoids. The biosynthesis of (-)-patchoulol and derivatives thereof, i.e. α-patchoulene β-patchoulene, γ-patchoulene and seychellene is depicted in the above pathway [Deguerry06] [Munck90].
The multifunctional enzyme patchoulol synthase catalyzing the convertion of (2E,6E)-farnesyl diphosphate into the various, structural very similar sesquiterpenoids is known to produce almost the whole fragrance cocktail of about 13 different sesquiterpenoid compounds reported in Pogostemon cablin [Deguerry06].
Deguerry06: Deguerry F, Pastore L, Wu S, Clark A, Chappell J, Schalk M (2006). "The diverse sesquiterpene profile of patchouli, Pogostemon cablin, is correlated with a limited number of sesquiterpene synthases." Arch Biochem Biophys 454(2);123-36. PMID: 16970904
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