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MetaCyc Pathway: superpathway of flavones and derivatives biosynthesis
Inferred from experiment

Pathway diagram: superpathway of flavones and derivatives biosynthesis

If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: Superpathways

Some taxa known to possess this pathway include : Arabidopsis thaliana col, Catharanthus roseus, Chrysosplenium americanum, Eustoma exaltatum russellianum, Flaveria bidentis, Flaveria chlorifolia, Medicago sativa, Petunia x hybrida, Pisum sativum, Pueraria montana lobata, Sesbania rostrata, Vigna radiata radiata

Expected Taxonomic Range: Viridiplantae

Subpathways: rutin biosynthesis, quercetin glycoside biosynthesis (Arabidopsis), methylquercetin biosynthesis, quercetin sulfate biosynthesis, kaempferol glycoside biosynthesis (Arabidopsis), kaempferol triglucoside biosynthesis, syringetin biosynthesis, flavonol biosynthesis

Unification Links: PlantCyc:PWY-6266

Created 03-Jun-2009 by Karthikeyan AS, TAIR

References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Ananvoranich94: Ananvoranich S, Varin L, Gulick P, Ibrahim R (1994). "Cloning and regulation of flavonol 3-sulfotransferase in cell-suspension cultures of Flaveria bidentis." Plant Physiol 106(2);485-91. PMID: 7991681

Barber62: Barber GA (1962). "Enzymic glycosylation of quercetin to rutin." Biochemistry 1;463-8. PMID: 13864833

Barber63: Barber GA (1963). "The formation of uridine diphosphate L-rhamnose by enzymes of the tobacco leaf." Arch Biochem Biophys 103;276-82. PMID: 14084592

Barber91: Barber GA, Behrman EJ (1991). "The synthesis and characterization of uridine 5'-(β-L-rhamnopyranosyl diphosphate) and its role in the enzymic synthesis of rutin." Arch Biochem Biophys 288(1);239-42. PMID: 1898019

Barron88: Barron, D, Varin, L, Ibrahim, R.K, Harborne, J.B, Williams C.A. (1988). "Sulphated flavonoids." Phytochemistry 27: 2375-2395.

Bredebach11: Bredebach M, Matern U, Martens S (2011). "Three 2-oxoglutarate-dependent dioxygenase activities of Equisetum arvense L. forming flavone and flavonol from (2S)-naringenin." Phytochemistry 72(7);557-63. PMID: 21353683

Brugliera99: Brugliera F, Barri-Rewell G, Holton TA, Mason JG (1999). "Isolation and characterization of a flavonoid 3'-hydroxylase cDNA clone corresponding to the Ht1 locus of Petunia hybrida." Plant J 19(4);441-51. PMID: 10504566

Buttery87: Buttery BR, Buzzell RI (1987). "Leaf Traits Associated with Flavonol Glycoside Genes in Soybean." Plant Physiol 85(1);20-21. PMID: 16665658

Cacace03: Cacace S, Schroder G, Wehinger E, Strack D, Schmidt J, Schroder J (2003). "A flavonol O-methyltransferase from Catharanthus roseus performing two sequential methylations." Phytochemistry 62(2);127-37. PMID: 12482447

Cosio84: Cosio EG, McClure JW (1984). "Kaempferol Glycosides and Enzymes of Flavonol Biosynthesis in Leaves of a Soybean Strain with Low Photosynthetic Rates." Plant Physiol 74(4);877-881. PMID: 16663526

Cristina11: Cristina Marcarini J, Ferreira Tsuboy MS, Cabral Luiz R, Regina Ribeiro L, Beatriz Hoffmann-Campo C, Segio Mantovani M (2011). "Investigation of cytotoxic, apoptosis-inducing, genotoxic and protective effects of the flavonoid rutin in HTC hepatic cells." Exp Toxicol Pathol 63(5);459-65. PMID: 20399630

De82: De Luca, V, Ibrahim, RG (1982). "Characterization of three distinct flavonol O-methyltransferases from Chrysosplenium americanum." Phytochemistry 21 1537-1540.

De85: De Luca V, Ibrahim RK (1985). "Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. I. Partial purification and some properties of S-adenosyl-L-methionine:flavonol 3-, 6-, 7-, and 4'-O-methyltransferases." Arch Biochem Biophys 238(2);596-605. PMID: 3994393

De85a: De Luca V, Ibrahim RK (1985). "Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. II. Substrate interaction and product inhibition studies of flavonol 3-, 6-, and 4'-O-methyltransferases." Arch Biochem Biophys 238(2);606-18. PMID: 3994394

Fujita06: Fujita A, Goto-Yamamoto N, Aramaki I, Hashizume K (2006). "Organ-specific transcription of putative flavonol synthase genes of grapevine and effects of plant hormones and shading on flavonol biosynthesis in grape berry skins." Biosci Biotechnol Biochem 70(3);632-8. PMID: 16556978

FukuchiMitzutan11: Fukuchi-Mitzutani M, Akagi M, Ishiguro K, Katsmoto Y, Fukui Y, Togami J (2011). "Biochemical and molecular characterization of anthocyanidin/flavonol 3-glucosylation pathways in Rosa x hybrida." Plant Biotechnology 28: 239-244.

Furuya65: Furuya M, Galston AW (1965). "Flavonoid complexes in Pisum sativum L.- I Nature and distribution of the maior components." Phytochemistry, 4, 285-296.

Gachon05: Gachon CM, Langlois-Meurinne M, Saindrenan P (2005). "Plant secondary metabolism glycosyltransferases: the emerging functional analysis." Trends Plant Sci 10(11);542-9. PMID: 16214386

Gauthier98: Gauthier A, Gulick PJ, Ibrahim RK (1998). "Characterization of two cDNA clones which encode O-methyltransferases for the methylation of both flavonoid and phenylpropanoid compounds." Arch Biochem Biophys 351(2);243-9. PMID: 9514654

Gene96: Gene RM, Cartana C, Adzet T, Marin E, Parella T, Canigueral S (1996). "Anti-inflammatory and analgesic activity of Baccharis trimera: identification of its active constituents." Planta Med 62(3);232-5. PMID: 8693035

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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