This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Superclasses:||Biosynthesis → Fatty Acid and Lipid Biosynthesis → Phospholipid Biosynthesis → Phosphatidylethanolamine Biosynthesis|
Expected Taxonomic Range: Eukaryota
Phospholipids are the major structural components of biological membranes in plants, animals, and yeasts. In plants, phospholipids predominate extra-chloroplast membranes including the plasma membrane, mitochondria membrane, endoplasmic reticulum, and microsomal membrane, with phosphatidylcholine and phosphatidylethanolamine being the major constituents. Phospholipids are mostly synthesized in the endoplasmic reticulum membrane. Once synthesized, they are transported to other phospholipid containing membranes.
At least three different pathways contribute to the biosynthesis of an L-1-phosphatidylethanolamine in plants: The decarboxylation pathway ( phosphatidylethanolamine biosynthesis I), the O-phosphoethanolamine transfer pathway ( phosphatidylethanolamine biosynthesis II), and the base (head group) exchange pathway ( phosphatidylethanolamine biosynthesis III). The phosphoethanolamine transfer pathway is believed to be the major pathway in plants.
Variants: cardiolipin and phosphatidylethanolamine biosynthesis (Xanthomonas), phosphatidylethanolamine biosynthesis I, phosphatidylethanolamine biosynthesis II, phospholipid remodeling (phosphatidylethanolamine, yeast)
Nerlich07: Nerlich A, von Orlow M, Rontein D, Hanson AD, Dormann P (2007). "Deficiency in phosphatidylserine decarboxylase activity in the psd1 psd2 psd3 triple mutant of Arabidopsis affects phosphatidylethanolamine accumulation in mitochondria." Plant Physiol 144(2);904-14. PMID: 17449644
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