MetaCyc Pathway: phosphatidylethanolamine biosynthesis III
Inferred from experiment

Enzyme View:

Pathway diagram: phosphatidylethanolamine biosynthesis III

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: BiosynthesisFatty Acid and Lipid BiosynthesisPhospholipid BiosynthesisPhosphatidylethanolamine Biosynthesis

Some taxa known to possess this pathway include : Arabidopsis thaliana col, Glycine max, Homo sapiens, Ricinus communis

Expected Taxonomic Range: Eukaryota

Phospholipids are the major structural components of biological membranes in plants, animals, and yeasts. In plants, phospholipids predominate extra-chloroplast membranes including the plasma membrane, mitochondria membrane, endoplasmic reticulum, and microsomal membrane, with phosphatidylcholine and phosphatidylethanolamine being the major constituents. Phospholipids are mostly synthesized in the endoplasmic reticulum membrane. Once synthesized, they are transported to other phospholipid containing membranes.

At least three different pathways contribute to the biosynthesis of an L-1-phosphatidylethanolamine in plants: The decarboxylation pathway ( phosphatidylethanolamine biosynthesis I), the O-phosphoethanolamine transfer pathway ( phosphatidylethanolamine biosynthesis II), and the base (head group) exchange pathway ( phosphatidylethanolamine biosynthesis III). The phosphoethanolamine transfer pathway is believed to be the major pathway in plants.

Citations: [Goode99, Nerlich07]

Variants: cardiolipin and phosphatidylethanolamine biosynthesis (Xanthomonas), phosphatidylethanolamine biosynthesis I, phosphatidylethanolamine biosynthesis II, phospholipid remodeling (phosphatidylethanolamine, yeast)

Created 10-Jun-2009 by Caspi R, SRI International


Goode99: Goode JH, Dewey RE (1999). "Characterization of aminoalcoholphosphotransferases from Arabidopsis thaliana and soybean." Plant Physiol. Biochem. 37(6): 445-457.

Nerlich07: Nerlich A, von Orlow M, Rontein D, Hanson AD, Dormann P (2007). "Deficiency in phosphatidylserine decarboxylase activity in the psd1 psd2 psd3 triple mutant of Arabidopsis affects phosphatidylethanolamine accumulation in mitochondria." Plant Physiol 144(2);904-14. PMID: 17449644

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Tomohiro09: Tomohiro S, Kawaguti A, Kawabe Y, Kitada S, Kuge O (2009). "Purification and characterization of human phosphatidylserine synthases 1 and 2." Biochem J 418(2);421-9. PMID: 19014349

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 20.0 (software by SRI International) on Thu May 5, 2016, BIOCYC13A.