MetaCyc Pathway: β-cubebene biosynthesis
Inferred from experiment

Enzyme View:

Pathway diagram: beta-cubebene biosynthesis

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: BiosynthesisSecondary Metabolites BiosynthesisTerpenoids BiosynthesisSesquiterpenoids Biosynthesis

Some taxa known to possess this pathway include : Magnolia, Magnolia grandiflora

Expected Taxonomic Range: Viridiplantae

Cubebenes are sesquiterpenes which have been isolated from a large number of flowering plants and they are commercially important as flavor ingredients in cosmetics and food products. During the history of the isolation and chemical synthesis of cubebenes there has been a confusing nomenclature, until it was finally resolved to be the same compound, namely Ylangene, copaene and cubebenes were classified as cubebenes [Veldhuis67]. The terpene synthase catalyzing betacubebene has been isolated from Magnolia, shown in the above pathway. Magnolia is an ancient evergreen tree and is cultivated for horticultural purposes as well as for the large number of natural products it produces [Lee08a]. Studies have also shown that the structural diversity of terpenes in Magnolia may be due to the diversity of terpene synthase (TPS) genes, which in turn diverged either due to loss of introns from an ancestor TPS gene or by gain of introns of progenate TPS genes [Lee08a]

Created 30-Jun-2009 by Pujar A, Boyce Thompson Institute


Lee08a: Lee S, Chappell J (2008). "Biochemical and genomic characterization of terpene synthases in Magnolia grandiflora." Plant Physiol 147(3);1017-33. PMID: 18467455

Veldhuis67: Veldhuis, M.K, Hunter, G.L.K (1967). "Nomenclature of Ylangene, Copaene and Cubebene." Journal of Food Science, 32, 697.

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Steele98: Steele CL, Crock J, Bohlmann J, Croteau R (1998). "Sesquiterpene synthases from grand fir (Abies grandis). Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization, and bacterial expression of delta-selinene synthase and gamma-humulene synthase." J Biol Chem 273(4);2078-89. PMID: 9442047

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed Jan 2, 2002, biocyc12.