MetaCyc Pathway: ω-hydroxylation of caprate and laurate

Pathway diagram: omega-hydroxylation of caprate and laurate

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: Biosynthesis Fatty Acid and Lipid Biosynthesis Fatty Acid Biosynthesis Unusual Fatty Acid Biosynthesis

Some taxa known to possess this pathway include ? : Petunia x hybrida

Expected Taxonomic Range: Viridiplantae

Plant membranes have a large component of fatty acids, which help in controlling the permeability of the membrane to solutes moving in and out of cells. A number of cytochrome P450 enzymes participate in fatty acid biosynthesis. Similar to mammalian fatty acid biosynthetic enzymes, plants also posses ω-fatty acid hydroxylases. In A. thaliana, a ω-fatty acid hydroxylase which catalyzes the ω-hydroxylation of saturated and unsaturated fatty acids [Hofer08] has been studied.

Omega fatty acids are postulated to play major roles in plant development and plant defense. In Petunia x hybrida the characterization of diverse fatty acids in the flower development stages and the enzymes catalyzing them indicate a significant role in stigma-pollen recognition [Imaishi99]. Hydroxylated fatty acids are components of cutin and suberin and play a protective role by deflecting microbial attack.

Created 16-Mar-2010 by Pujar A , Boyce Thompson Institute


Hofer08: Hofer R, Briesen I, Beck M, Pinot F, Schreiber L, Franke R (2008). "The Arabidopsis cytochrome P450 CYP86A1 encodes a fatty acid omega-hydroxylase involved in suberin monomer biosynthesis." J Exp Bot 59(9);2347-60. PMID: 18544608

Imaishi07: Imaishi H, Petkova-Andonova M (2007). "Molecular cloning of CYP76B9, a cytochrome P450 from Petunia hybrida, catalyzing the omega-hydroxylation of capric acid and lauric acid." Biosci Biotechnol Biochem 71(1);104-13. PMID: 17213671

Imaishi99: Imaishi H, Matsumoto Y, Ishitobi U, Ohkawa H (1999). "Encoding of a cytochrome P450-dependent lauric acid monooxygenase by CYP703A1 specifically expressed in the floral buds of petunia hybrida." Biosci Biotechnol Biochem 63(12);2082-90. PMID: 10664841

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Benveniste82: Benveniste I, Salaun JP, Simon A, Reichhart D, Durst F (1982). "Cytochrome P-450-Dependent omega-Hydroxylation of Lauric Acid by Microsomes from Pea Seedlings." Plant Physiol 70(1);122-126. PMID: 16662431

Hunt06: Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs." FASEB J 20(11);1855-64. PMID: 16940157

Isbell06: Isbell, T.A, Lowery, B.A, DeKeyser, S.S, Winchell, A.L, Cermak, S.C (2006). "Physical properties of triglyceride estolides from lesquerella and castor oils." Industrial Crops and Products, 23, 256-263.

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Rubio06: Rubio S, Larson TR, Gonzalez-Guzman M, Alejandro S, Graham IA, Serrano R, Rodriguez PL (2006). "An Arabidopsis mutant impaired in coenzyme A biosynthesis is sugar dependent for seedling establishment." Plant Physiol 140(3);830-43. PMID: 16415216

Salaun81: Salaun JP, Benveniste I, Reichhart D, Durst F (1981). "Induction and specificity of a (cytochrome P-450)-dependent laurate in-chain-hydroxylase from higher plant microsomes." Eur J Biochem 119(3);651-5. PMID: 7308207

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Jun 2, 2015, biocyc13.