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discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Pathway: adenine and adenosine salvage II

Enzyme View:

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: Biosynthesis Nucleosides and Nucleotides Biosynthesis Purine Nucleotide Biosynthesis Purine Nucleotide Salvage Adenine and Adenosine Salvage

Some taxa known to possess this pathway include ? : Arabidopsis thaliana col , Halobacterium salinarum , Homo sapiens Inferred from experiment [Spychala96], Mycoplasma pneumoniae M129

Expected Taxonomic Range: Archaea , Bacteria , Eukaryota

Summary:
Adenosine nucleotides can be synthesized de novo. In that route AMP (AMP) is synthesized via IMP (IMP) and adenylo-succinate, which is converted to AMP by the action of adenylosuccinate lyase (see superpathway of adenosine nucleotides de novo biosynthesis II). Note that the free base adenine or the ribonucleoside adenosine are not produced via the de novo pathway.

Many organisms can also recycle adenosine nucleotides by a combination of degradation and salvage pathways. The degradation pathways are responsible for the conversion of the nucleotides to the nucleoside (adenosine) and free base form (adenine), and further degradation to compounds that can be catabolized to basic building blocks (for example, see adenosine nucleotides degradation II).

However, both adenosine and adenine can be salvaged by certain enzymes, and be converted back to nucleotide form.

The enzyme adenosine kinase (EC 2.7.1.20) can phosphorylate adenosine directly to the mono-nucleotide AMP. The enzyme has been described in bacteria, yeast, plants and animals [Leibach71, Spychala96, Moffatt00, Wang05c, Rajkarnikar07, Lu09].

Other routes from adenosine to AMP involve two steps, and are described in adenine and adenosine salvage I and adenine and adenosine salvage II.

Either of these routes enables the organism to salvage the degradation products of adenosine nucleotides, and recycle them back to nucleotide form.

Superpathways: superpathway of purine nucleotide salvage

Variants: adenine and adenosine salvage I , adenine and adenosine salvage II , adenine and adenosine salvage III , adenine and adenosine salvage IV , adenine and adenosine salvage V

Credits:
Created 27-Sep-2010 by Caspi R , SRI International


References

Leibach71: Leibach TK, Spiess GI, Neudecker TJ, Peschke GJ, Puchwein G, Hartmann GR (1971). "Purification and properties of adenosine kinase from dried brewer's yeast." Hoppe Seylers Z Physiol Chem 352(3);328-44. PMID: 5092557

Lu09: Lu GT, Tang YQ, Li CY, Li RF, An SQ, Feng JX, He YQ, Jiang BL, Tang DJ, Tang JL (2009). "An adenosine kinase exists in Xanthomonas campestris pathovar campestris and is involved in extracellular polysaccharide production, cell motility, and virulence." J Bacteriol 191(11);3639-48. PMID: 19329636

Moffatt00: Moffatt BA, Wang L, Allen MS, Stevens YY, Qin W, Snider J, von Schwartzenberg K (2000). "Adenosine kinase of Arabidopsis. Kinetic properties and gene expression." Plant Physiol 124(4);1775-85. PMID: 11115893

Rajkarnikar07: Rajkarnikar A, Kwon HJ, Suh JW (2007). "Role of adenosine kinase in the control of Streptomyces differentiations: Loss of adenosine kinase suppresses sporulation and actinorhodin biosynthesis while inducing hyperproduction of undecylprodigiosin in Streptomyces lividans." Biochem Biophys Res Commun 363(2);322-8. PMID: 17869216

Spychala96: Spychala J, Datta NS, Takabayashi K, Datta M, Fox IH, Gribbin T, Mitchell BS (1996). "Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases." Proc Natl Acad Sci U S A 93(3);1232-7. PMID: 8577746

Wang05c: Wang Y, Long MC, Ranganathan S, Escuyer V, Parker WB, Li R (2005). "Overexpression, purification and crystallographic analysis of a unique adenosine kinase from Mycobacterium tuberculosis." Acta Crystallogr Sect F Struct Biol Cryst Commun 61(Pt 6);553-7. PMID: 16511094

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Mathews98: Mathews II, Erion MD, Ealick SE (1998). "Structure of human adenosine kinase at 1.5 A resolution." Biochemistry 37(45);15607-20. PMID: 9843365

McNally97: McNally T, Helfrich RJ, Cowart M, Dorwin SA, Meuth JL, Idler KB, Klute KA, Simmer RL, Kowaluk EA, Halbert DN (1997). "Cloning and expression of the adenosine kinase gene from rat and human tissues." Biochem Biophys Res Commun 231(3);645-50. PMID: 9070863


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, biocyc12.