This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Superclasses:||Biosynthesis → Secondary Metabolites Biosynthesis → Phenylpropanoid Derivatives Biosynthesis → Stilbenes Biosynthesis|
Some taxa known to possess this pathway include : Vitis vinifera
Expected Taxonomic Range: Viridiplantae
The compound pterostilbene is a stilbene produced by a number of plants as a defense response compound. Its localization varies in different plant species, it is commonly found in leaves and fruits such as Vitis vinifera and blueberries, in the heartwood of sandalwood trees, and in barks of Guibourtia tessmanii [Fuendjiep02]. pterostilbene has been subjected to a number of pharmacological studies because of their known medicinal properties in folk medicine. Its chemical structure is very similar to trans-resveratrol, but because of its double methylated nature it carries higher bioavailability [Kapetanovic10], and thus has a higher transport rate into cells. Based on animal studies, pterostilbene has been shown to be effective as an antineoplastic [Mannal10] antiinflammatory as well as anti-oxidant agent and all these properties are reviewed in this monograph . In this pathway, the methyltransferase enzymes responsible for the formation of pterostilbene from the precursor trans-resveratrol via 3-methoxy-4',5-dihydroxy-trans-stilbene has been cloned [Schmidlin08].
Fuendjiep02: Fuendjiep V, Wandji J, Tillequin F, Mulholland DA, Budzikiewicz H, Fomum ZT, Nyemba AM, Koch M (2002). "Chalconoid and stilbenoid glycosides from Guibourtia tessmanii." Phytochemistry 60(8);803-6. PMID: 12150803
Kapetanovic10: Kapetanovic IM, Muzzio M, Huang Z, Thompson TN, McCormick DL (2010). "Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats." Cancer Chemother Pharmacol. PMID: 21116625
Schmidlin08: Schmidlin L, Poutaraud A, Claudel P, Mestre P, Prado E, Santos-Rosa M, Wiedemann-Merdinoglu S, Karst F, Merdinoglu D, Hugueney P (2008). "A stress-inducible resveratrol O-methyltransferase involved in the biosynthesis of pterostilbene in grapevine." Plant Physiol 148(3);1630-9. PMID: 18799660
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