This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Superclasses:||Biosynthesis → Nucleosides and Nucleotides Biosynthesis → Purine Nucleotide Biosynthesis|
Expected Taxonomic Range: cellular organisms
A study that looked for the compound in cell extracts found it in a range of organisms including Chlorella pyrenoidosa, Euglena gracilis, Spinacia oleracea, Hordeum vulgare, Dictyostelium discoideum and Escherichia coli [Fankhauser81].
The degradation of adenosine 5'-phosphoramidate has been studied in yellow Lupin (Lupinus luteus) by using the nucleotide analog adenosine 5'-phosphorothioate. The study showed that the lupin adenosine 5'-phosphoramidase splits the P-S bond in adenosine 5'-phosphorothioate, similarly to the action of HINT4 proteins in Arabidopsis [Guranowski11].
Fankhauser81: Fankhauser H, Schiff JA, Garber LJ (1981). "Purification and properties of adenylyl sulphate:ammonia adenylyltransferase from Chlorella catalysing the formation of adenosine 5' -phosphoramidate from adenosine 5' -phosphosulphate and ammonia." Biochem J 195(3);545-60. PMID: 6274307
Fankhauser81a: Fankhauser H, Berkowitz GA, Schiff JA (1981). "A nucleotide with the properties of adenosine 5' phosphoramidate from Chlorella cells." Biochem Biophys Res Commun 101(2);524-32. PMID: 7306093
Guranowski11: Guranowski A, Wojdyla AM, Rydzik AM, Stepinski J, Jemielity J (2011). "Plant nucleoside 5'-phosphoramidate hydrolase; simple purification from yellow lupin (Lupinus luteus) seeds and properties of homogeneous enzyme." Acta Biochim Pol 58(1);131-6. PMID: 21403921
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