This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Superclasses:||Degradation/Utilization/Assimilation → Carbohydrates Degradation → Sugars Degradation|
Some taxa known to possess this pathway include : Escherichia coli K-12 substr. MG1655
Escherichia coli is able to utilize melibiose as a sole source of carbon. Melibiose is imported by the melibiose permease, MelB. The melibiose is then converted to β-D-glucose and β-D-galactose by the α-galactosidase encoded by melA.
Unification Links: EcoCyc:PWY0-1301
Bruel11: Bruel L, Sulzenbacher G, Cervera Tison M, Pujol A, Nicoletti C, Perrier J, Galinier A, Ropartz D, Fons M, Pompeo F, Giardina T (2011). "α-Galactosidase/sucrose kinase (AgaSK), a novel bifunctional enzyme from the human microbiome coupling galactosidase and kinase activities." J Biol Chem 286(47);40814-23. PMID: 21931163
Hanatani84: Hanatani M, Yazyu H, Shiota-Niiya S, Moriyama Y, Kanazawa H, Futai M, Tsuchiya T (1984). "Physical and genetic characterization of the melibiose operon and identification of the gene products in Escherichia coli." J Biol Chem 259(3);1807-12. PMID: 6319412
Legler86: Legler G, Pohl S (1986). "Synthesis of 5-amino-5-deoxy-D-galactopyranose and 1,5-dideoxy-1,5-imino-D-galactitol, and their inhibition of alpha- and beta-D-galactosidases." Carbohydr Res 155;119-29. PMID: 3024831
Liebl98: Liebl W, Wagner B, Schellhase J (1998). "Properties of an alpha-galactosidase, and structure of its gene galA, within an alpha-and beta-galactoside utilization gene cluster of the hyperthermophilic bacterium Thermotoga maritima." Syst Appl Microbiol 1998;21(1);1-11. PMID: 9741105
Mandrich02: Mandrich L, Caputo E, Martin BM, Rossi M, Manco G (2002). "The Aes protein and the monomeric alpha-galactosidase from Escherichia coli form a non-covalent complex. Implications for the regulation of carbohydrate metabolism." J Biol Chem 277(50);48241-7. PMID: 12374803
Nagao88: Nagao Y, Nakada T, Imoto M, Shimamoto T, Sakai S, Tsuda M, Tsuchiya T (1988). "Purification and analysis of the structure of alpha-galactosidase from Escherichia coli." Biochem Biophys Res Commun 1988;151(1);236-41. PMID: 2831880
Pourcher90: Pourcher T, Bassilana M, Sarkar HK, Kaback HR, Leblanc G (1990). "Melibiose permease and alpha-galactosidase of Escherichia coli: identification by selective labeling using a T7 RNA polymerase/promoter expression system." Biochemistry 29(3);690-6. PMID: 2159786
Shimamoto94: Shimamoto T, Noguchi K, Kuroda M, Tsuda M, Tsuchiya T (1994). "Transcriptional attenuation and differential mRNA stability in the regulation of the Escherichia coli melibiose operon." J Biochem 115(6);1185-9. PMID: 7982902
©2014 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493