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MetaCyc Pathway: sedoheptulose bisphosphate bypass

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: Generation of Precursor Metabolites and Energy

Some taxa known to possess this pathway include ? : Escherichia coli K-12 substr. MG1655

Expected Taxonomic Range: Bacteria , Eukaryota

Summary:
In Escherichia coli K-12, accumulation of D-sedoheptulose 7-phosphate, an intermediate of the pentose phosphate pathway (non-oxidative branch), leads to its utilization via the sedoheptulose bisphospate bypass pathway, described here. The pathway was discovered due to the unexpected near-wild type growth of a talA talB double null mutant on xylose [Nakahigashi09].

6-phosphofructokinase I is able to phosphorylate D-sedoheptulose 7-phosphate, producing D-sedoheptulose-1,7-bisphosphate, which is in turn split into dihydroxyacetone phosphate and D-erythrose 4-phosphate by fructose bisphosphate aldolase [Nakahigashi09].

Unification Links: EcoCyc:PWY0-1517

Credits:
Created 23-Sep-2010 by Keseler I , SRI International


References

Nakahigashi09: Nakahigashi K, Toya Y, Ishii N, Soga T, Hasegawa M, Watanabe H, Takai Y, Honma M, Mori H, Tomita M (2009). "Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism." Mol Syst Biol 5;306. PMID: 19756045

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Alefounder89: Alefounder PR, Perham RN (1989). "Identification, molecular cloning and sequence analysis of a gene cluster encoding the class II fructose 1,6-bisphosphate aldolase, 3-phosphoglycerate kinase and a putative second glyceraldehyde 3-phosphate dehydrogenase of Escherichia coli." Mol Microbiol 3(6);723-32. PMID: 2546007

Alefounder89a: Alefounder PR, Baldwin SA, Perham RN, Short NJ (1989). "Cloning, sequence analysis and over-expression of the gene for the class II fructose 1,6-bisphosphate aldolase of Escherichia coli." Biochem J 1989;257(2);529-34. PMID: 2649077

Auzat94: Auzat I, Le Bras G, Garel JR (1994). "The cooperativity and allosteric inhibition of Escherichia coli phosphofructokinase depend on the interaction between threonine-125 and ATP." Proc Natl Acad Sci U S A 91(12);5242-6. PMID: 8202475

Auzat94a: Auzat I, Le Bras G, Branny P, De La Torre F, Theunissen B, Garel JR (1994). "The role of Glu187 in the regulation of phosphofructokinase by phosphoenolpyruvate." J Mol Biol 235(1);68-72. PMID: 7904653

Auzat95: Auzat I, Byrnes WM, Garel JR, Chang SH (1995). "Role of residue 161 in the allosteric transitions of two bacterial phosphofructokinases." Biochemistry 34(21);7062-8. PMID: 7766616

Auzat95a: Auzat I, Le Bras G, Garel JR (1995). "Hypercooperativity induced by interface mutations in the phosphofructokinase from Escherichia coli." J Mol Biol 246(2);248-53. PMID: 7869376

Auzat95b: Auzat I, Gawlita E, Garel JR (1995). "Slow ligand-induced transitions in the allosteric phosphofructokinase from Escherichia coli." J Mol Biol 249(2);478-92. PMID: 7783204

Auzat97: Auzat I, Le Bras G, Garel JR (1997). "Allosteric activation increases the maximum velocity of E. coli phosphofructokinase." J Mol Biol 267(3);476-80. PMID: 9126831

Babul88: Babul J, Fraenkel DG (1988). "Phosphate modification of fructose-1,6-bisphosphate aldolase in Escherichia coli." Biochem Biophys Res Commun 151(3);1033-8. PMID: 3281666

Babul93: Babul J, Clifton D, Kretschmer M, Fraenkel DG (1993). "Glucose metabolism in Escherichia coli and the effect of increased amount of aldolase." Biochemistry 32(17);4685-92. PMID: 8485146

Baldwin78a: Baldwin SA, Perham RN, Stribling D (1978). "Purification and characterization of the class-II D-fructose 1,6-bisphosphate aldolase from Escherichia coli (Crookes' strain)." Biochem J 1978;169(3);633-41. PMID: 417719

Berger90: Berger SA, Evans PR (1990). "Active-site mutants altering the cooperativity of E. coli phosphofructokinase." Nature 343(6258);575-6. PMID: 2137204

Berger91: Berger SA, Evans PR (1991). "Steady-state fluorescence of Escherichia coli phosphofructokinase reveals a regulatory role for ATP." Biochemistry 1991;30(34);8477-80. PMID: 1832014

Berger92: Berger SA, Evans PR (1992). "Site-directed mutagenesis identifies catalytic residues in the active site of Escherichia coli phosphofructokinase." Biochemistry 31(38);9237-42. PMID: 1390710

Berry93: Berry A, Marshall KE (1993). "Identification of zinc-binding ligands in the class II fructose-1,6-bisphosphate aldolase of Escherichia coli." FEBS Lett 318(1);11-6. PMID: 8436219

Blangy68: Blangy D, Buc H, Monod J (1968). "Kinetics of the allosteric interactions of phosphofructokinase from Escherichia coli." J Mol Biol 31(1);13-35. PMID: 4229913

Blangy68a: Blangy D (1968). "Phosphofructokinase from E. Coli: Evidence for a tetrameric structure of the enzyme." FEBS Lett 2(2);109-111. PMID: 11946283

Blom96: Blom NS, Tetreault S, Coulombe R, Sygusch J (1996). "Novel active site in Escherichia coli fructose 1,6-bisphosphate aldolase." Nat Struct Biol 3(10);856-62. PMID: 8836102

Bock66: Bock A, Neidhardt FC (1966). "Properties of a Mutant of Escherichia coli with a Temperature-sensitive Fructose-1,6-Diphosphate Aldolase." J Bacteriol 92(2);470-6. PMID: 16562137

Bock66a: Bock A, Neidhardt FC (1966). "Isolation of a Mutant of Escherichia coli with a Temperature-sensitive Fructose-1,6-Diphosphate Aldolase Activity." J Bacteriol 92(2);464-469. PMID: 16562136

Showing only 20 references. To show more, press the button "Show all references".


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, biocyc13.