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MetaCyc Pathway: phosphatidylethanolamine biosynthesis II
Inferred from experiment

Enzyme View:

Pathway diagram: phosphatidylethanolamine biosynthesis II

This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.

Superclasses: BiosynthesisFatty Acid and Lipid BiosynthesisPhospholipid BiosynthesisPhosphatidylethanolamine Biosynthesis

Some taxa known to possess this pathway include : Arabidopsis thaliana col, Glycine max, Ricinus communis

Expected Taxonomic Range: Eukaryota

Phospholipids are the major structural components of biological membranes in plants, animals, and yeasts. In plants, phospholipids predominate extra-chloroplast membranes including the plasma membrane, mitochondria membrane, endoplasmic reticulum, and microsomal membrane, with phosphatidylcholine and phosphatidylethanolamine being the major constituents. Phospholipids are mostly synthesized in the endoplasmic reticulum membrane. Once synthesized, they are transported to other phospholipid containing membranes.

At least three different pathways contribute to the biosynthesis of an L-1-phosphatidylethanolamine in plants: The decarboxylation pathway ( phosphatidylethanolamine biosynthesis I), the O-phosphoethanolamine transfer pathway ( phosphatidylethanolamine biosynthesis II), and the base (head group) exchange pathway ( phosphatidylethanolamine biosynthesis III). The phosphoethanolamine transfer pathway (this one) is believed to be the major pathway in plants.

Citations: [Goode99, Nerlich07]

Superpathways: superpathway of phospholipid biosynthesis II (plants)

Variants: cardiolipin and phosphatidylethanolamine biosynthesis (Xanthomonas), phosphatidylethanolamine biosynthesis I, phosphatidylethanolamine biosynthesis III, phospholipid remodeling (phosphatidylethanolamine, yeast)

Created 29-Sep-2008 by Zhang P, TAIR


Goode99: Goode JH, Dewey RE (1999). "Characterization of aminoalcoholphosphotransferases from Arabidopsis thaliana and soybean." Plant Physiol. Biochem. 37(6): 445-457.

Nerlich07: Nerlich A, von Orlow M, Rontein D, Hanson AD, Dormann P (2007). "Deficiency in phosphatidylserine decarboxylase activity in the psd1 psd2 psd3 triple mutant of Arabidopsis affects phosphatidylethanolamine accumulation in mitochondria." Plant Physiol 144(2);904-14. PMID: 17449644

Other References Related to Enzymes, Genes, Subpathways, and Substrates of this Pathway

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Macher76: Macher BA, Mudd JB (1976). "Partial purification and properties of ethanolamine kinase from spinach leaf." Arch Biochem Biophys 177(1);24-30. PMID: 187122

Mizoi06: Mizoi J, Nakamura M, Nishida I (2006). "Defects in CTP:PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE affect embryonic and postembryonic development in Arabidopsis." Plant Cell 18(12);3370-85. PMID: 17189343

Nuccio00: Nuccio ML, Ziemak MJ, Henry SA, Weretilnyk EA, Hanson AD (2000). "cDNA cloning of phosphoethanolamine N-methyltransferase from spinach by complementation in Schizosaccharomyces pombe and characterization of the recombinant enzyme." J Biol Chem 275(19);14095-101. PMID: 10799484

Rontein01: Rontein D, Nishida I, Tashiro G, Yoshioka K, Wu WI, Voelker DR, Basset G, Hanson AD (2001). "Plants synthesize ethanolamine by direct decarboxylation of serine using a pyridoxal phosphate enzyme." J Biol Chem 276(38);35523-9. PMID: 11461929

Summers93: Summers PS, Weretilnyk EA (1993). "Choline Synthesis in Spinach in Relation to Salt Stress." Plant Physiol 103(4);1269-1276. PMID: 12232019

Wang91: Wang XM, Moore TS (1991). "Phosphatidylethanolamine synthesis by castor bean endosperm. Intracellular distribution and characteristics of CTP:ethanolaminephosphate cytidylyltransferase." J Biol Chem 266(30);19981-7. PMID: 1657910

Wharfe79: Wharfe J, Harwood JL (1979). "Lipid metabolism in germinating seeds. Purification of ethanolamine kinase from soya bean." Biochim Biophys Acta 575(1);102-11. PMID: 228735

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sun May 1, 2016, biocyc13.