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MetaCyc Enzyme: fatty acyl Δ15 desaturase (endoplasmic reticulum)

Gene: FAD3 Accession Number: AT2G29980 (MetaCyc)

Synonyms: At2g29980

Species: Arabidopsis thaliana col

Subunit composition of fatty acyl Δ15 desaturase (endoplasmic reticulum) = [FAD3]
         ω-3 fatty acid desaturase monomer = FAD3

Summary:
ER linoleate desaturase introduces a third double bond (delta-15) in linolenate in linolenate-containing phosphatidylcholine, an important extra-plastidial membrane lipid.

Citations: [Browse93]

Locations: endoplasmic reticulum membrane, endoplasmic reticulum

Molecular Weight of Polypeptide: 44.077 kD (from nucleotide sequence)

Unification Links: ArrayExpress:P48623 , PhylomeDB:P48623 , Protein Model Portal:P48623 , String:P48623 , TAIR:AT2G29980 , UniProt:P48623

Relationship Links: InterPro:IN-FAMILY:IPR005804 , InterPro:IN-FAMILY:IPR021863 , Pfam:IN-FAMILY:PF00487 , Pfam:IN-FAMILY:PF11960

Gene-Reaction Schematic: ?

GO Terms:

Cellular Component: GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Credits:
Created 06-Aug-2008 by Caspi R , SRI International


Enzymatic reaction of: linolenate Δ15 desaturase (fatty acyl Δ15 desaturase (endoplasmic reticulum))

EC Number: 1.14.19.-

a lipid linoleoyl group + a reduced electron acceptor + oxygen <=> a lipid α-linolenoyl group + an oxidized electron acceptor + 2 H2O

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

In Pathways: α-linolenate biosynthesis


Enzymatic reaction of: 1-16:0-2-18:2-phosphatidylcholine desaturase (fatty acyl Δ15 desaturase (endoplasmic reticulum))

EC Number: 1.14.19.-

1-palmitoyl-2-linoleoyl-phosphatidylcholine + a reduced electron acceptor + oxygen <=> 1-16:0-2-18:3-phosphatidylcholine + an oxidized electron acceptor + 2 H2O

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is favored in the direction shown.

In Pathways: phospholipid desaturation


Enzymatic reaction of: 1-18:3-2-18:2-phosphatidylcholine desaturase (fatty acyl Δ15 desaturase (endoplasmic reticulum))

EC Number: 1.14.19.-

1-18:3-2-18:2-phosphatidylcholine + a reduced electron acceptor + oxygen <=> 1-18:3-2-18:3-phosphatidylcholine + an oxidized electron acceptor + 2 H2O

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

In Pathways: phospholipid desaturation


Enzymatic reaction of: 1-18:2-2-18:3-phosphatidylcholine desaturase (fatty acyl Δ15 desaturase (endoplasmic reticulum))

EC Number: 1.14.19.-

1-18:2-2-18:3-phosphatidylcholine + a reduced electron acceptor + oxygen <=> 1-18:3-2-18:3-phosphatidylcholine + an oxidized electron acceptor + 2 H2O

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

In Pathways: phospholipid desaturation


Enzymatic reaction of: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase (fatty acyl Δ15 desaturase (endoplasmic reticulum))

EC Number: 1.14.19.-

1-18:2-2-18:2-sn-glycerol-3-phosphocholine + a reduced electron acceptor + oxygen <=> 1-18:3-2-18:2-phosphatidylcholine + an oxidized electron acceptor + 2 H2O

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

In Pathways: phospholipid desaturation


Enzymatic reaction of: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase (fatty acyl Δ15 desaturase (endoplasmic reticulum))

EC Number: 1.14.19.-

1-18:2-2-18:2-sn-glycerol-3-phosphocholine + a reduced electron acceptor + oxygen <=> 1-18:2-2-18:3-phosphatidylcholine + an oxidized electron acceptor + 2 H2O

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

In Pathways: phospholipid desaturation


Enzymatic reaction of: 1-18:1-2-18:2-phosphatidylcholine desaturase (fatty acyl Δ15 desaturase (endoplasmic reticulum))

EC Number: 1.14.19.-

1-18:1-2-18:2-phosphatidylcholine + a reduced electron acceptor + oxygen <=> 1-18:1-2-18:3-phosphatidylcholine + an oxidized electron acceptor + 2 H2O

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

In Pathways: phospholipid desaturation


Enzymatic reaction of: 1-18:2-2-18:1-phosphatidylcholine desaturase (fatty acyl Δ15 desaturase (endoplasmic reticulum))

EC Number: 1.14.19.-

1-18:2-2-18:1-phosphatidylcholine + a reduced electron acceptor + oxygen <=> 1-18:3-2-18:1-phosphatidylcholine + an oxidized electron acceptor + 2 H2O

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

In Pathways: phospholipid desaturation


References

Browse93: Browse J, McConn M, James D, Miquel M (1993). "Mutants of Arabidopsis deficient in the synthesis of alpha-linolenate. Biochemical and genetic characterization of the endoplasmic reticulum linoleoyl desaturase." J Biol Chem 1993;268(22);16345-51. PMID: 8102138

Yadav93: Yadav NS, Wierzbicki A, Aegerter M, Caster CS, Perez-Grau L, Kinney AJ, Hitz WD, Booth JR, Schweiger B, Stecca KL (1993). "Cloning of higher plant omega-3 fatty acid desaturases." Plant Physiol 103(2);467-76. PMID: 8029334


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, BIOCYC14B.