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MetaCyc Enzyme: Dipeptidase 2 / LTD4 dipeptidase 2

Gene: DPEP2 Accession Number: HS09532 (MetaCyc)

Synonyms: UNQ284/PRO323

Species: Homo sapiens

Subunit composition of Dipeptidase 2 / LTD4 dipeptidase 2 = [DPEP2]2
         Dipeptidase 2 = DPEP2

Map Position: [68,399,040 <- 68,412,217]

Unification Links: ArrayExpress:Q9H4A9, Ensembl:ENSG00000167261, Entrez-gene:64174, Entrez-Nucleotide:AJ295149, Entrez-Nucleotide:AK092884, Entrez-Nucleotide:BC024021, Entrez:AAH24021, Entrez:CAC14667, GeneCards:LOC64174, PhylomeDB:Q9H4A9, Pride:Q9H4A9, Protein Model Portal:Q9H4A9, RefSeq:NM_022355, RefSeq:NP_071750, SMR:Q9H4A9, String:9606.ENSP00000377430, UCSC Human Genome:NM_022355, UniGene:115537, UniProt:Q9H4A9

Relationship Links: InterPro:IN-FAMILY:IPR000180, InterPro:IN-FAMILY:IPR008257, InterPro:IN-FAMILY:IPR028531, Panther:IN-FAMILY:PTHR10443, Panther:IN-FAMILY:PTHR10443:SF9, Pfam:IN-FAMILY:PF01244, Prosite:IN-FAMILY:PS00869, Prosite:IN-FAMILY:PS51365

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [a dipeptide + H2O → 2 amino acids] (3.4.13.19):
i1: L-glutamyl-L-glutamate + H2O → 2 L-glutamate (3.4.13.7)


GO Terms:
Biological Process:
GO:0006508 - proteolysis []
Molecular Function:
GO:0008239 - dipeptidyl-peptidase activity []

Credits:
Created 26-Jun-2010 by Trupp M, SRI International


Enzymatic reaction of: Dipeptidase 2

EC Number: 3.4.13.19

a dipeptide + H2O → 2 amino acids

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.


Enzymatic reaction of: LTD4 dipeptidase 2

Inferred from experiment

EC Number: 3.4.13.19

leukotriene-D4 + H2O → glycine + leukotriene-E4

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

In Pathways: leukotriene biosynthesis

Exons/Introns

Schematic showing introns, exons and/or isoforms of DPEP2


References

Habib03: Habib GM, Shi ZZ, Cuevas AA, Lieberman MW (2003). "Identification of two additional members of the membrane-bound dipeptidase family." FASEB J 17(10);1313-5. PMID: 12738806


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed May 4, 2016, biocyc13.