MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsProtein-Modification Reactions
Reactions Classified By SubstrateMacromolecule ReactionsProtein-ReactionsProtein-Modification Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: lysophosphatidate acyltransferaseInferred from experiment: ATS2
Escherichia coli K-12 substr. MG1655: 1-acylglycerol-3-phosphate O-acyltransferaseInferred from experiment: plsC
Saccharomyces cerevisiae: 1-acyl-sn-gylcerol-3-phosphate acyl transferase: SLC1
Streptococcus pneumoniae R6: 1-acylglycerol-3-phosphate acyltransferaseInferred from experiment: plsC

In Pathway: CDP-diacylglycerol biosynthesis III, CDP-diacylglycerol biosynthesis II

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 1-acylglycerol-3-phosphate O-acyltransferase

Enzyme Commission Synonyms: 1-acyl-sn-glycero-3-phosphate acyltransferase, 1-acyl-sn-glycerol 3-phosphate acyltransferase, 1-acylglycero-3-phosphate acyltransferase, 1-acylglycerolphosphate acyltransferase, 1-acylglycerophosphate acyltransferase, lysophosphatidic acid-acyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -3.6099854Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acyl-[acyl-carrier protein] can also act as an acyl donor. The animal enzyme is specific for the transfer of unsaturated fatty acyl groups.

Citations: [Frentzen83, Hill68, Yamashita73]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [a triglyceride + H2O → a 1,2-diglyceride + a fatty acid + H+] (
i6: tributyrin + H2O → 1,2-dibutyrin + butanoate + H+ (

Instance reaction of [a phosphatidylcholine + H2O → a 1-acyl 2-lyso-phosphatidylcholine + a long-chain fatty acid + H+] (
i7: 1,2-dipalmitoyl-phosphatidylcholine + H2O → 1-16:0-2-lysophosphatidylcholine + palmitate + H+ (

Instance reactions of [a steryl-ester + H2O → a fatty acid + a sterol + H+] (
i4: ergosteryl oleate + H2O → ergosterol + oleate + H+ (

i5: lanosteryl oleate + H2O → lanosterol + oleate + H+ (

Instance reaction of [an acyl-CoA + a 1-acyl 2-lyso-phosphatidylcholine ↔ a phosphatidylcholine + coenzyme A] (
i1: palmitoyl-CoA + 1-16:0-2-lysophosphatidylcholine ↔ 1,2-dipalmitoyl-phosphatidylcholine + coenzyme A (

Instance reactions of [a long-chain acyl-CoA + a 1-acyl-sn-glycerol 3-phosphate → a 1,2-diacyl-sn-glycerol 3-phosphate + coenzyme A] (
i8: palmitoleoyl-CoA + 1-myristoylglycerol 3-phosphate → 1-myristoyl-2-palmitoleoyl phosphatidate + coenzyme A (

i9: palmitoleoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate → 1-cis-vaccenoyl-2-palmitoleoyl phosphatidate + coenzyme A (

i10: palmitoleoyl-CoA + 1-palmitoylglycerol 3-phosphate → 1-palmitoyl-2-palmitoleoyl phosphatidate + coenzyme A (

i11: 1-palmitoylglycerol 3-phosphate + myristoyl-CoA → 1-palmitoyl-2-myristoyl phosphatidate + coenzyme A (

i12: myristoyl-CoA + 1-myristoylglycerol 3-phosphate → dimyristoyl phosphatidate + coenzyme A (

i13: cis-vaccenoyl-CoA + 1-cis-vaccenoylglycerol-3-phosphate → 1,2-dicis-vaccenoyl-phosphatidate + coenzyme A (

i14: cis-vaccenoyl-CoA + 1-palmitoylglycerol 3-phosphate → 1-palmitoyl-2-cis-vaccenoyl phosphatidate + coenzyme A (

Unification Links: KEGG:R09381

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O07584, UniProt:RELATED-TO:O07807, UniProt:RELATED-TO:O07808, UniProt:RELATED-TO:O07809, UniProt:RELATED-TO:O25903, UniProt:RELATED-TO:O35083, UniProt:RELATED-TO:O53516, UniProt:RELATED-TO:O84459, UniProt:RELATED-TO:P0A257, UniProt:RELATED-TO:P26647, UniProt:RELATED-TO:P44848, UniProt:RELATED-TO:P74498, UniProt:RELATED-TO:P75479, UniProt:RELATED-TO:Q9JU41, UniProt:RELATED-TO:Q9KP63, UniProt:RELATED-TO:Q9PHZ5, UniProt:RELATED-TO:Q9RRA7, UniProt:RELATED-TO:Q9S2M2, UniProt:RELATED-TO:Q9US20, UniProt:RELATED-TO:Q9XDL6, UniProt:RELATED-TO:Q9Z7Y4, UniProt:RELATED-TO:Q9ZBS1, UniProt:RELATED-TO:Q9ZD75, UniProt:RELATED-TO:Q9ZJN8, UniProt:RELATED-TO:Q22267, UniProt:RELATED-TO:Q42870, UniProt:RELATED-TO:Q49402, UniProt:RELATED-TO:Q59188, UniProt:RELATED-TO:Q59601, UniProt:RELATED-TO:Q59618, UniProt:RELATED-TO:Q93841


Frentzen83: Frentzen M, Heinz E, McKeon TA, Stumpf PK (1983). "Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts." Eur J Biochem 129(3);629-36. PMID: 6825679

Hill68: Hill EE, Lands WE (1968). "Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine." Biochim Biophys Acta 152(3);645-8. PMID: 5661029

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Yamashita73: Yamashita S, Hosaka K, Numa S (1973). "Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes." Eur J Biochem 38(1);25-31. PMID: 4774123

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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