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June 28th 2015
Join us at the Metabolomics Conference tutorial
June 28th 2015
Join us at the Metabolomics Conference tutorial
June 28th 2015
Join us at the Metabolomics Conference tutorial
June 28th 2015
Join us at the Metabolomics Conference tutorial
June 28th 2015

MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col : lysophosphatidate acyltransferase Inferred from experiment : ATS2
Escherichia coli K-12 substr. MG1655 : 1-acylglycerol-3-phosphate O-acyltransferase Inferred from experiment : plsC
Saccharomyces cerevisiae : 1-acyl-sn-gylcerol-3-phosphate acyl transferase : SLC1
Streptococcus pneumoniae R6 : 1-acylglycerol-3-phosphate acyltransferase Inferred from experiment : plsC

In Pathway: CDP-diacylglycerol biosynthesis III , CDP-diacylglycerol biosynthesis II

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 1-acylglycerol-3-phosphate O-acyltransferase

Enzyme Commission Synonyms: 1-acyl-sn-glycero-3-phosphate acyltransferase, 1-acyl-sn-glycerol 3-phosphate acyltransferase, 1-acylglycero-3-phosphate acyltransferase, 1-acylglycerolphosphate acyltransferase, 1-acylglycerophosphate acyltransferase, lysophosphatidic acid-acyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -3.6099854 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acyl-[acyl-carrier protein] can also act as an acyl donor. The animal enzyme is specific for the transfer of unsaturated fatty acyl groups.

Citations: [Frentzen83, Hill68, Yamashita73]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [an acyl-CoA + a 1-acyl 2-lyso-phosphatidylcholine ↔ a phosphatidylcholine + coenzyme A] (
i1: palmitoyl-CoA + 1-16:0-2-lysophosphatidylcholine ↔ 1,2-dipalmitoyl-phosphatidylcholine + coenzyme A (

Instance reaction of [a phosphatidylcholine + H2O → a 1-acyl 2-lyso-phosphatidylcholine + a long-chain fatty acid + H+] (
i7: 1,2-dipalmitoyl-phosphatidylcholine + H2O → 1-16:0-2-lysophosphatidylcholine + palmitate + H+ (

Instance reaction of [an L-1-phosphatidylethanolamine[periplasmic space] + H2O[periplasmic space] → a fatty acid[periplasmic space] + a 1-acyl 2-lyso-phosphatidylethanolamine[periplasmic space] + H+[periplasmic space]] (
i3: 1-18:1-2-18:1-phosphatidylethanolamine + H2O → 1-18:1-lysophosphatidylethanolamine + oleate + H+ (

Instance reaction of [a triglyceride + H2O → a 1,2-diglyceride + a fatty acid + H+] (
i6: tributyrin + H2O → 1,2-dibutyrin + butanoate + H+ (

Instance reactions of [a steryl-ester + H2O → a fatty acid + a sterol + H+] (
i4: ergosteryl oleate + H2O → ergosterol + oleate + H+ (

i5: lanosteryl oleate + H2O → lanosterol + oleate + H+ (

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , UniProt:RELATED-TO:O07584 , UniProt:RELATED-TO:O07807 , UniProt:RELATED-TO:O07808 , UniProt:RELATED-TO:O07809 , UniProt:RELATED-TO:O25903 , UniProt:RELATED-TO:O35083 , UniProt:RELATED-TO:O53516 , UniProt:RELATED-TO:O84459 , UniProt:RELATED-TO:P0A257 , UniProt:RELATED-TO:P26647 , UniProt:RELATED-TO:P44848 , UniProt:RELATED-TO:P74498 , UniProt:RELATED-TO:P75479 , UniProt:RELATED-TO:Q9JU41 , UniProt:RELATED-TO:Q9KP63 , UniProt:RELATED-TO:Q9PHZ5 , UniProt:RELATED-TO:Q9RRA7 , UniProt:RELATED-TO:Q9S2M2 , UniProt:RELATED-TO:Q9US20 , UniProt:RELATED-TO:Q9XDL6 , UniProt:RELATED-TO:Q9Z7Y4 , UniProt:RELATED-TO:Q9ZBS1 , UniProt:RELATED-TO:Q9ZD75 , UniProt:RELATED-TO:Q9ZJN8 , UniProt:RELATED-TO:Q22267 , UniProt:RELATED-TO:Q42870 , UniProt:RELATED-TO:Q49402 , UniProt:RELATED-TO:Q59188 , UniProt:RELATED-TO:Q59601 , UniProt:RELATED-TO:Q59618 , UniProt:RELATED-TO:Q93841


Frentzen83: Frentzen M, Heinz E, McKeon TA, Stumpf PK (1983). "Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts." Eur J Biochem 129(3);629-36. PMID: 6825679

Hill68: Hill EE, Lands WE (1968). "Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine." Biochim Biophys Acta 152(3);645-8. PMID: 5661029

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Yamashita73: Yamashita S, Hosaka K, Numa S (1973). "Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes." Eur J Biochem 38(1);25-31. PMID: 4774123

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Jun 30, 2015, biocyc14.