Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.1.1.278

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.278

Enzymes and Genes:
NADPH:3α-hydroxysteroid 5α-oxidoreductase Inferred from experiment ( Digitalis lanata )
Aldo-keto reductase family 1 member C4 : AKR1C4 ( Homo sapiens )
Aldo-keto reductase family 1 member C3 : AKR1C3 ( Homo sapiens )
Aldo-keto reductase family 1 member C1 : AKR1C1 ( Homo sapiens )
3α hydroxysteroid dehydrogenase III : AKR1C2 ( Homo sapiens )

In Pathway: cardenolide biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
allopregnanolone + NAD(P)+ ↔ 5-α-pregnane-3,20-dione + NAD(P)H + H+ (1.1.1.213)

Enzyme Commission Primary Name: 3β-hydroxy-5α-steroid dehydrogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -1.6264954 Inferred by computational analysis [Latendresse13]

Citations: [Warneck]

Gene-Reaction Schematic: ?

Instance reactions of [testosterone + NAD(P)+ → androst-4-ene-3,17-dione + NAD(P)H + H+] (1.1.1.51):
i3: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+ (1.1.1.239)

i4: testosterone + NADP+ ← androst-4-ene-3,17-dione + NADPH + H+ (1.1.1.64)

Instance reactions of [allopregnanolone + NAD(P)+ ↔ 5-α-pregnane-3,20-dione + NAD(P)H + H+] (1.1.1.213):
i1: allopregnanolone + NAD+ → 5-α-pregnane-3,20-dione + NADH + H+ (1.1.-.-)

i2: allopregnanolone + NADP+ ← 5-α-pregnane-3,20-dione + NADPH + H+ (1.1.1.278)

Unification Links: KEGG:R07138 , Rhea:18137

Relationship Links: BRENDA:EC:1.1.1.278 , ENZYME:EC:1.1.1.278 , IUBMB-ExplorEnz:EC:1.1.1.278


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Warneck: Warneck HM, Seitz HU "3 beta-hydroxysteroid oxidoreductase in suspension cultures of Digitalis lanata EHRH." Z Naturforsch C 45(9-10);963-72. PMID: 2291772


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, biocyc14.