|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.118
Enzymes and Genes:
|Digitalis lanata:||NADPH:3α-hydroxysteroid 5α-oxidoreductase|
|Homo sapiens:||3α hydroxysteroid dehydrogenase III: AKR1C2|
Aldo-keto reductase family 1 member C1: AKR1C1
Aldo-keto reductase family 1 member C3: AKR1C3
Aldo-keto reductase family 1 member C4: AKR1C4
In Pathway: cardenolide biosynthesis
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Direct generic reaction:
allopregnanolone + NAD(P)+ ↔ 5-α-pregnane-3,20-dione + NAD(P)H + H+ (18.104.22.168)
Enzyme Commission Primary Name: 3β-hydroxy-5α-steroid dehydrogenase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -1.6264954 [Latendresse13]
Instance reactions of [allopregnanolone + NAD(P)+ ↔ 5-α-pregnane-3,20-dione + NAD(P)H + H+] (22.214.171.124):
i1: allopregnanolone + NAD+ → 5-α-pregnane-3,20-dione + NADH + H+ (1.1.-.-)
i2: allopregnanolone + NADP+ ← 5-α-pregnane-3,20-dione + NADPH + H+ (126.96.36.1998)
©2016 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493