|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 22.214.171.1248
Enzymes and Genes:
|Digitalis lanata:||NADPH:3α-hydroxysteroid 5α-oxidoreductase|
|Homo sapiens:||3α hydroxysteroid dehydrogenase III: AKR1C2|
Aldo-keto reductase family 1 member C1: AKR1C1
Aldo-keto reductase family 1 member C3: AKR1C3
Aldo-keto reductase family 1 member C4: AKR1C4
In Pathway: cardenolide biosynthesis
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Direct generic reaction:
allopregnanolone + NAD(P)+ ↔ 5-α-pregnane-3,20-dione + NAD(P)H + H+ (126.96.36.199)
Enzyme Commission Primary Name: 3β-hydroxy-5α-steroid dehydrogenase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -1.6264954 [Latendresse13]
Instance reactions of [testosterone + NAD(P)+ → androst-4-ene-3,17-dione + NAD(P)H + H+] (188.8.131.52):
i3: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+ (184.108.40.206)
i4: testosterone + NADP+ ← androst-4-ene-3,17-dione + NADPH + H+ (220.127.116.11)
Instance reactions of [allopregnanolone + NAD(P)+ ↔ 5-α-pregnane-3,20-dione + NAD(P)H + H+] (18.104.22.168):
i1: allopregnanolone + NAD+ → 5-α-pregnane-3,20-dione + NADH + H+ (1.1.-.-)
i2: allopregnanolone + NADP+ ← 5-α-pregnane-3,20-dione + NADPH + H+ (22.214.171.1248)
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