Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

MetaCyc Reaction: 1.1.1.8

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.8

Enzymes and Genes:
glycerol 3-phosphate dehydrogenase Inferred from experiment : GPD1 ( Saccharomyces cerevisiae )
glycerol-3-phosphate dehydrogenase (NAD-dependent) Inferred from experiment : At2G41540 ( Arabidopsis thaliana col )
cytoplasmic glycerol-3-phosphate dehydrogenase (NAD+) Inferred from experiment : GPD1 ( Homo sapiens )
glycerol-3-phosphate dehydrogenase : gpsA ( Clostridium acetobutylicum )
glycerol-3-phosphate dehydrogenase, biosynthetic : gpsA ( Escherichia coli K-12 substr. MG1655 )

In Pathway: glycerol-3-phosphate shuttle , 1,3-propanediol biosynthesis (engineered) , superpathway phosphatidate biosynthesis (yeast)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
sn-glycerol 3-phosphate + NAD(P)+ ← dihydroxyacetone phosphate + NAD(P)H + H+ (1.1.1.94)

Enzyme Commission Primary Name: glycerol-3-phosphate dehydrogenase (NAD+)

Enzyme Commission Synonyms: α-glycerol phosphate dehydrogenase (NAD+), α-glycerophosphate dehydrogenase (NAD+), glycerol 1-phosphate dehydrogenase, glycerol phosphate dehydrogenase (NAD+), glycerophosphate dehydrogenase (NAD+), hydroglycerophosphate dehydrogenase, L-α-glycerol phosphate dehydrogenase, L-α-glycerophosphate dehydrogenase, L-glycerol phosphate dehydrogenase, L-glycerophosphate dehydrogenase (ambiguous), NAD+-α-glycerophosphate dehydrogenase, NAD+-dependent glycerol phosphate dehydrogenase, NAD+-dependent glycerol-3-phosphate dehydrogenase, NAD+-L-glycerol-3-phosphate dehydrogenase, NAD+-linked glycerol 3-phosphate dehydrogenase, NADH-dihydroxyacetone phosphate reductase, glycerol-3-phosphate dehydrogenase (NAD+), L-glycerol-3-phosphate dehydrogenase (ambiguous)

Standard Gibbs Free Energy (ΔrG in kcal/mol): 4.1518555 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also acts on propane-1,2-diol phosphate and glycerone sulfate (but with a much lower affinity).

Citations: [Albertyn92, Koekemoer95, Warkentin73, OBrien72, Brosemer69]

Gene-Reaction Schematic: ?

Instance reaction of [sn-glycerol 3-phosphate + NAD(P)+ ← dihydroxyacetone phosphate + NAD(P)H + H+] (1.1.1.94):
i1: sn-glycerol 3-phosphate + NAD+ ↔ dihydroxyacetone phosphate + NADH + H+ (1.1.1.8)

Unification Links: KEGG:R00842

Relationship Links: BRENDA:EC:1.1.1.8 , ENZYME:EC:1.1.1.8 , IUBMB-ExplorEnz:EC:1.1.1.8 , UniProt:RELATED-TO:O25614 , UniProt:RELATED-TO:O29390 , UniProt:RELATED-TO:P07735 , UniProt:RELATED-TO:P08507 , UniProt:RELATED-TO:P0A6S7 , UniProt:RELATED-TO:P13706 , UniProt:RELATED-TO:P13707 , UniProt:RELATED-TO:P21695 , UniProt:RELATED-TO:P34517 , UniProt:RELATED-TO:P41911 , UniProt:RELATED-TO:P43798 , UniProt:RELATED-TO:P46919 , UniProt:RELATED-TO:P90593 , UniProt:RELATED-TO:Q9JWH0 , UniProt:RELATED-TO:Q00055


References

Albertyn92: Albertyn J, van Tonder A, Prior BA (1992). "Purification and characterization of glycerol-3-phosphate dehydrogenase of Saccharomyces cerevisiae." FEBS Lett 308(2);130-2. PMID: 1499720

Brosemer69: Brosemer RW, Kuhn RW (1969). "Comparative structural properties of honeybee and rabbit alpha-glycerophosphate dehydrogenases." Biochemistry 8(5);2095-105. PMID: 4307630

Koekemoer95: Koekemoer TC, Litthauer D, Oelofsen W (1995). "Isolation and characterization of adipose tissue glycerol-3-phosphate dehydrogenase." Int J Biochem Cell Biol 27(6);625-32. PMID: 7671141

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

OBrien72: O'Brien SJ, MacIntyre RJ (1972). "The -glycerophosphate cycle in Drosophila melanogaster. I. Biochemical and developmental aspects." Biochem Genet 7(2);141-61. PMID: 4340553

Warkentin73: Warkentin DL, Fondy TP (1973). "Isolation and characterization of cytoplasmic L-glycerol-3-phosphate dehydrogenase from rabbit-renal-adipose tissue and its comparison with the skeletal-muscle enzyme." Eur J Biochem 36(1);97-109. PMID: 4200180


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Nov 24, 2014, biocyc14.