|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
|Arabidopsis thaliana col :||glycerol-3-phosphate dehydrogenase (NAD-dependent)
|Clostridium acetobutylicum :||glycerol-3-phosphate dehydrogenase
|Escherichia coli K-12 substr. MG1655 :||glycerol-3-phosphate dehydrogenase, biosynthetic
|Homo sapiens :||cytoplasmic glycerol-3-phosphate dehydrogenase (NAD+)
|Saccharomyces cerevisiae :||glycerol 3-phosphate dehydrogenase
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Direct generic reaction:
sn-glycerol 3-phosphate + NAD(P)+ ← glycerone phosphate + NAD(P)H + H+ (22.214.171.124)
Enzyme Commission Primary Name: glycerol-3-phosphate dehydrogenase (NAD+)
Enzyme Commission Synonyms: α-glycerol phosphate dehydrogenase (NAD+), α-glycerophosphate dehydrogenase (NAD+), glycerol 1-phosphate dehydrogenase, glycerol phosphate dehydrogenase (NAD+), glycerophosphate dehydrogenase (NAD+), hydroglycerophosphate dehydrogenase, L-α-glycerol phosphate dehydrogenase, L-α-glycerophosphate dehydrogenase, L-glycerol phosphate dehydrogenase, L-glycerophosphate dehydrogenase (ambiguous), NAD+-α-glycerophosphate dehydrogenase, NAD+-dependent glycerol phosphate dehydrogenase, NAD+-dependent glycerol-3-phosphate dehydrogenase, NAD+-L-glycerol-3-phosphate dehydrogenase, NAD+-linked glycerol 3-phosphate dehydrogenase, NADH-dihydroxyacetone phosphate reductase, glycerol-3-phosphate dehydrogenase (NAD+), L-glycerol-3-phosphate dehydrogenase (ambiguous)
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 4.1518555 [Latendresse13]
Enzyme Commission Summary:
Also acts on propane-1,2-diol phosphate and glycerone sulfate (but with a much lower affinity).
Instance reaction of [sn-glycerol 3-phosphate + NAD(P)+ ← glycerone phosphate + NAD(P)H + H+] (126.96.36.199):
i1: sn-glycerol 3-phosphate + NAD+ ↔ glycerone phosphate + NADH + H+ (188.8.131.52)
Unification Links: KEGG:R00842
Relationship Links: BRENDA:EC:184.108.40.206 , ENZYME:EC:220.127.116.11 , IUBMB-ExplorEnz:EC:18.104.22.168 , UniProt:RELATED-TO:O25614 , UniProt:RELATED-TO:O29390 , UniProt:RELATED-TO:P07735 , UniProt:RELATED-TO:P08507 , UniProt:RELATED-TO:P0A6S7 , UniProt:RELATED-TO:P13706 , UniProt:RELATED-TO:P13707 , UniProt:RELATED-TO:P21695 , UniProt:RELATED-TO:P34517 , UniProt:RELATED-TO:P41911 , UniProt:RELATED-TO:P43798 , UniProt:RELATED-TO:P46919 , UniProt:RELATED-TO:P90593 , UniProt:RELATED-TO:Q9JWH0 , UniProt:RELATED-TO:Q00055
Warkentin73: Warkentin DL, Fondy TP (1973). "Isolation and characterization of cytoplasmic L-glycerol-3-phosphate dehydrogenase from rabbit-renal-adipose tissue and its comparison with the skeletal-muscle enzyme." Eur J Biochem 36(1);97-109. PMID: 4200180
©2015 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493