Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
twitter

MetaCyc Reaction: 1.1.99.28

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 1.1.99.28

Enzymes and Genes:

Zymomonas mobilis: glucose-fructose oxidoreductaseInferred from experiment: gfo

In Pathway: sorbitol biosynthesis II

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glucose-fructose oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -5.630005Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
D-mannose, D-xylose, D-galactose, 2-deoxy-D-glucose and L-arabinose will function as aldose substrates, but with low affinities. The ketose substrate must be in the open-chain form. The apparent affinity for fructose is low, because little of the fructose substrate is in the open-chain form. Xylulose and glycerone (dihydroxyacetone) will replace fructose, but they are poor substrates. The enzyme from Zymomonas mobilis contains tightly bound NADP+.

Citations: [Zachariou86, Hardman88, Kanagasundaram92]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R00874, Rhea:20637

Relationship Links: BRENDA:EC:1.1.99.28, ENZYME:EC:1.1.99.28, IUBMB-ExplorEnz:EC:1.1.99.28


References

Hardman88: Hardman MJ, Scopes RK (1988). "The kinetics of glucose-fructose oxidoreductase from Zymomonas mobilis." Eur J Biochem 173(1);203-9. PMID: 3356190

Kanagasundaram92: Kanagasundaram V, Scopes RK (1992). "Cloning, sequence analysis, and expression of the structural gene encoding glucose-fructose oxidoreductase from Zymomonas mobilis." J Bacteriol 174(5);1439-47. PMID: 1537789

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Zachariou86: Zachariou M, Scopes RK (1986). "Glucose-fructose oxidoreductase, a new enzyme isolated from Zymomonas mobilis that is responsible for sorbitol production." J Bacteriol 167(3);863-9. PMID: 3745122


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Feb 6, 2016, biocyc11.