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MetaCyc Reaction: 1.10.2.2

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Composite Reactions Electron-Transfer-Reactions
Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 1.10.2.2

Enzymes and Genes:

Arabidopsis thaliana col : ubiquinol-cytochrome c oxidoreductase Traceable author statement to experimental support : at3g16480 , at1g51980 , at3g02090 , at3g27240 , at5g40810 , at5g13440
Nitrosomonas europaea : cytochrome cm552 Inferred from experiment : cycB
Saccharomyces cerevisiae : ubiquinol-cytochrome C oxidoreductase : QCR10

In Pathway: ammonia oxidation IV (autotrophic ammonia oxidizers) , aerobic respiration II (cytochrome c) (yeast) , aerobic respiration I (cytochrome c)

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

Transport reaction diagram

Reaction Locations: mitochondrial inner membrane, inner membrane (sensu Gram-negative Bacteria)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: quinol—cytochrome-c reductase

Enzyme Commission Synonyms: ubiquinol-cytochrome-c reductase, coenzyme Q-cytochrome c reductase, dihydrocoenzyme Q-cytochrome c reductase, reduced ubiquinone-cytochrome c reductase, complex III (mitochondrial electron transport), ubiquinone-cytochrome c reductase, ubiquinol-cytochrome c oxidoreductase, reduced coenzyme Q-cytochrome c reductase, ubiquinone-cytochrome c oxidoreductase, reduced ubiquinone-cytochrome c oxidoreductase, mitochondrial electron transport complex III, ubiquinol-cytochrome c-2 oxidoreductase, ubiquinone-cytochrome b-c1 oxidoreductase, ubiquinol-cytochrome c2 reductase, ubiquinol-cytochrome c1 oxidoreductase, CoQH2-cytochrome c oxidoreductase, ubihydroquinol:cytochrome c oxidoreductase, coenzyme QH2-cytochrome c reductase, QH2:cytochrome c oxidoreductase, ubiquinol:ferricytochrome-c oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -23.014221 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Contains cytochromes b-562, b-566 and c1, and a 2-iron ferredoxin. Depending on the organism and physiological conditions, either two or four protons are extruded from the cytoplasmic to the non-cytoplasmic compartment (cf. EC 1.6.99.3 NADH dehydrogenase).

Citations: [Marres77, Rieske76, Wikstrom81]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:1.10.2.2 , ENZYME:EC:1.10.2.2 , IUBMB-ExplorEnz:EC:1.10.2.2 , UniProt:RELATED-TO:O03176 , UniProt:RELATED-TO:O03548 , UniProt:RELATED-TO:O21291 , UniProt:RELATED-TO:O21337 , UniProt:RELATED-TO:O26064 , UniProt:RELATED-TO:O26065 , UniProt:RELATED-TO:O44512 , UniProt:RELATED-TO:O47499 , UniProt:RELATED-TO:O47545 , UniProt:RELATED-TO:O47575 , UniProt:RELATED-TO:O47878 , UniProt:RELATED-TO:O54070 , UniProt:RELATED-TO:O63585 , UniProt:RELATED-TO:O63621 , UniProt:RELATED-TO:O63748 , UniProt:RELATED-TO:O63910 , UniProt:RELATED-TO:O66459 , UniProt:RELATED-TO:O66460 , UniProt:RELATED-TO:O79386 , UniProt:RELATED-TO:O79413 , UniProt:RELATED-TO:O79558 , UniProt:RELATED-TO:O79571 , UniProt:RELATED-TO:O79680 , UniProt:RELATED-TO:O79715 , UniProt:RELATED-TO:O79717 , UniProt:RELATED-TO:O97134 , UniProt:RELATED-TO:O99606 , UniProt:RELATED-TO:O99815 , UniProt:RELATED-TO:O99828 , UniProt:RELATED-TO:O99971 , UniProt:RELATED-TO:P00125 , UniProt:RELATED-TO:P00126 , UniProt:RELATED-TO:P00127 , UniProt:RELATED-TO:P00128 , UniProt:RELATED-TO:P00130 , UniProt:RELATED-TO:P00157 , UniProt:RELATED-TO:P00158 , UniProt:RELATED-TO:P00159 , UniProt:RELATED-TO:P00160 , UniProt:RELATED-TO:P00161 , UniProt:RELATED-TO:P00162 , UniProt:RELATED-TO:P00163 , UniProt:RELATED-TO:P00164 , UniProt:RELATED-TO:P04165 , UniProt:RELATED-TO:P05417 , UniProt:RELATED-TO:P05418 , UniProt:RELATED-TO:P05718 , UniProt:RELATED-TO:P07056 , UniProt:RELATED-TO:P07142 , UniProt:RELATED-TO:P07143 , UniProt:RELATED-TO:P07256 , UniProt:RELATED-TO:P07257 , UniProt:RELATED-TO:P07704 , UniProt:RELATED-TO:P07747 , UniProt:RELATED-TO:P07919 , UniProt:RELATED-TO:P08067 , UniProt:RELATED-TO:P08500 , UniProt:RELATED-TO:P08501 , UniProt:RELATED-TO:P08502 , UniProt:RELATED-TO:P08525 , UniProt:RELATED-TO:P08574 , UniProt:RELATED-TO:P09843 , UniProt:RELATED-TO:P11669 , UniProt:RELATED-TO:P12778 , UniProt:RELATED-TO:P13271 , UniProt:RELATED-TO:P13272 , UniProt:RELATED-TO:P13627 , UniProt:RELATED-TO:P14548 , UniProt:RELATED-TO:P15547 , UniProt:RELATED-TO:P15585 , UniProt:RELATED-TO:P16357 , UniProt:RELATED-TO:P16358 , UniProt:RELATED-TO:P16359 , UniProt:RELATED-TO:P16360 , UniProt:RELATED-TO:P16363 , UniProt:RELATED-TO:P16364 , UniProt:RELATED-TO:P16366 , UniProt:RELATED-TO:P16367 , UniProt:RELATED-TO:P16536 , UniProt:RELATED-TO:P18935 , UniProt:RELATED-TO:P18946 , UniProt:RELATED-TO:P20114 , UniProt:RELATED-TO:P20788 , UniProt:RELATED-TO:P21713 , UniProt:RELATED-TO:P21714 , UniProt:RELATED-TO:P21715 , UniProt:RELATED-TO:P21716 , UniProt:RELATED-TO:P21717 , UniProt:RELATED-TO:P21718 , UniProt:RELATED-TO:P21719 , UniProt:RELATED-TO:P21720 , UniProt:RELATED-TO:P21721 , UniProt:RELATED-TO:P21722 , UniProt:RELATED-TO:P21723 , UniProt:RELATED-TO:P22289 , UniProt:RELATED-TO:P22695 , UniProt:RELATED-TO:P23004 , UniProt:RELATED-TO:P23134 , UniProt:RELATED-TO:P23135 , UniProt:RELATED-TO:P23136 , UniProt:RELATED-TO:P23663 , UniProt:RELATED-TO:P24878 , UniProt:RELATED-TO:P24890 , UniProt:RELATED-TO:P24950 , UniProt:RELATED-TO:P24951 , UniProt:RELATED-TO:P24952 , UniProt:RELATED-TO:P24953 , UniProt:RELATED-TO:P24954 , UniProt:RELATED-TO:P24955 , UniProt:RELATED-TO:P24956 , UniProt:RELATED-TO:P24957 , UniProt:RELATED-TO:P24958 , UniProt:RELATED-TO:P24959 , UniProt:RELATED-TO:P24960 , UniProt:RELATED-TO:P24962 , UniProt:RELATED-TO:P24964 , UniProt:RELATED-TO:P24965 , UniProt:RELATED-TO:P24966 , UniProt:RELATED-TO:P24992 , UniProt:RELATED-TO:P25076 , UniProt:RELATED-TO:P26852 , UniProt:RELATED-TO:P29630 , UniProt:RELATED-TO:P29631 , UniProt:RELATED-TO:P29632 , UniProt:RELATED-TO:P29633 , UniProt:RELATED-TO:P29634 , UniProt:RELATED-TO:P29635 , UniProt:RELATED-TO:P29636 , UniProt:RELATED-TO:P29637 , UniProt:RELATED-TO:P29638 , UniProt:RELATED-TO:P29639 , UniProt:RELATED-TO:P29640 , UniProt:RELATED-TO:P29641 , UniProt:RELATED-TO:P29757 , UniProt:RELATED-TO:P31800 , UniProt:RELATED-TO:P31930 , UniProt:RELATED-TO:P32551 , UniProt:RELATED-TO:P34197 , UniProt:RELATED-TO:P34844 , UniProt:RELATED-TO:P34845 , UniProt:RELATED-TO:P34861 , UniProt:RELATED-TO:P34863 , UniProt:RELATED-TO:P37299 , UniProt:RELATED-TO:P37841 , UniProt:RELATED-TO:P38593 , UniProt:RELATED-TO:P38594 , UniProt:RELATED-TO:P41280 ... [212 more not displayed]

Credits:
Revised 26-Jul-2012 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Marres77: Marres CM, Slater EC (1977). "Polypeptide composition of purified QH2:cytochrome c oxidoreductase from beef-heart mitochondria." Biochim Biophys Acta 462(3);531-48. PMID: 597492

Rieske76: Rieske JS (1976). "Composition, structure, and function of complex III of the respiratory chain." Biochim Biophys Acta 456(2);195-247. PMID: 788795

Wikstrom81: Wikstrom M, Krab K, Saraste M (1981). "Proton-translocating cytochrome complexes." Annu Rev Biochem 50;623-55. PMID: 6267990


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Jun 30, 2015, biocyc14.