Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.10.2.2

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Composite Reactions Electron-Transfer-Reactions
Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 1.10.2.2

Enzymes and Genes:
ubiquinol-cytochrome C oxidoreductase : QCR10 ( Saccharomyces cerevisiae )
cytochrome cm552 Inferred from experiment : cycB ( Nitrosomonas europaea )
ubiquinol-cytochrome c oxidoreductase Traceable author statement to experimental support : at3g16480 , at1g51980 , at3g02090 , at3g27240 , at5g40810 , at5g13440 ( Arabidopsis thaliana col )

In Pathway: ammonia oxidation IV (autotrophic ammonia oxidizers) , aerobic respiration II (cytochrome c) (yeast) , aerobic respiration I (cytochrome c)

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

Reaction Locations: mitochondrial inner membrane, inner membrane (sensu Gram-negative Bacteria)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: quinol—cytochrome-c reductase

Enzyme Commission Synonyms: ubiquinol-cytochrome-c reductase, coenzyme Q-cytochrome c reductase, dihydrocoenzyme Q-cytochrome c reductase, reduced ubiquinone-cytochrome c reductase, complex III (mitochondrial electron transport), ubiquinone-cytochrome c reductase, ubiquinol-cytochrome c oxidoreductase, reduced coenzyme Q-cytochrome c reductase, ubiquinone-cytochrome c oxidoreductase, reduced ubiquinone-cytochrome c oxidoreductase, mitochondrial electron transport complex III, ubiquinol-cytochrome c-2 oxidoreductase, ubiquinone-cytochrome b-c1 oxidoreductase, ubiquinol-cytochrome c2 reductase, ubiquinol-cytochrome c1 oxidoreductase, CoQH2-cytochrome c oxidoreductase, ubihydroquinol:cytochrome c oxidoreductase, coenzyme QH2-cytochrome c reductase, QH2:cytochrome c oxidoreductase, ubiquinol:ferricytochrome-c oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -23.014221 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Contains cytochromes b-562, b-566 and c1, and a 2-iron ferredoxin. Depending on the organism and physiological conditions, either two or four protons are extruded from the cytoplasmic to the non-cytoplasmic compartment (cf. EC 1.6.99.3 NADH dehydrogenase).

Citations: [Marres77, Rieske76, Wikstrom81]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:1.10.2.2 , ENZYME:EC:1.10.2.2 , IUBMB-ExplorEnz:EC:1.10.2.2 , UniProt:RELATED-TO:O03176 , UniProt:RELATED-TO:O03548 , UniProt:RELATED-TO:O21291 , UniProt:RELATED-TO:O21337 , UniProt:RELATED-TO:O26064 , UniProt:RELATED-TO:O26065 , UniProt:RELATED-TO:O44512 , UniProt:RELATED-TO:O47499 , UniProt:RELATED-TO:O47545 , UniProt:RELATED-TO:O47575 , UniProt:RELATED-TO:O47878 , UniProt:RELATED-TO:O54070 , UniProt:RELATED-TO:O63585 , UniProt:RELATED-TO:O63621 , UniProt:RELATED-TO:O63748 , UniProt:RELATED-TO:O63910 , UniProt:RELATED-TO:O66459 , UniProt:RELATED-TO:O66460 , UniProt:RELATED-TO:O79386 , UniProt:RELATED-TO:O79413 , UniProt:RELATED-TO:O79558 , UniProt:RELATED-TO:O79571 , UniProt:RELATED-TO:O79680 , UniProt:RELATED-TO:O79715 , UniProt:RELATED-TO:O79717 , UniProt:RELATED-TO:O97134 , UniProt:RELATED-TO:O99606 , UniProt:RELATED-TO:O99815 , UniProt:RELATED-TO:O99828 , UniProt:RELATED-TO:O99971 , UniProt:RELATED-TO:P00125 , UniProt:RELATED-TO:P00126 , UniProt:RELATED-TO:P00127 , UniProt:RELATED-TO:P00128 , UniProt:RELATED-TO:P00130 , UniProt:RELATED-TO:P00157 , UniProt:RELATED-TO:P00158 , UniProt:RELATED-TO:P00159 , UniProt:RELATED-TO:P00160 , UniProt:RELATED-TO:P00161 , UniProt:RELATED-TO:P00162 , UniProt:RELATED-TO:P00163 , UniProt:RELATED-TO:P00164 , UniProt:RELATED-TO:P04165 , UniProt:RELATED-TO:P05417 , UniProt:RELATED-TO:P05418 , UniProt:RELATED-TO:P05718 , UniProt:RELATED-TO:P07056 , UniProt:RELATED-TO:P07142 , UniProt:RELATED-TO:P07143 , UniProt:RELATED-TO:P07256 , UniProt:RELATED-TO:P07257 , UniProt:RELATED-TO:P07704 , UniProt:RELATED-TO:P07747 , UniProt:RELATED-TO:P07919 , UniProt:RELATED-TO:P08067 , UniProt:RELATED-TO:P08500 , UniProt:RELATED-TO:P08501 , UniProt:RELATED-TO:P08502 , UniProt:RELATED-TO:P08525 , UniProt:RELATED-TO:P08574 , UniProt:RELATED-TO:P09843 , UniProt:RELATED-TO:P11669 , UniProt:RELATED-TO:P12778 , UniProt:RELATED-TO:P13271 , UniProt:RELATED-TO:P13272 , UniProt:RELATED-TO:P13627 , UniProt:RELATED-TO:P14548 , UniProt:RELATED-TO:P15547 , UniProt:RELATED-TO:P15585 , UniProt:RELATED-TO:P16357 , UniProt:RELATED-TO:P16358 , UniProt:RELATED-TO:P16359 , UniProt:RELATED-TO:P16360 , UniProt:RELATED-TO:P16363 , UniProt:RELATED-TO:P16364 , UniProt:RELATED-TO:P16366 , UniProt:RELATED-TO:P16367 , UniProt:RELATED-TO:P16536 , UniProt:RELATED-TO:P18935 , UniProt:RELATED-TO:P18946 , UniProt:RELATED-TO:P20114 , UniProt:RELATED-TO:P20788 , UniProt:RELATED-TO:P21713 , UniProt:RELATED-TO:P21714 , UniProt:RELATED-TO:P21715 , UniProt:RELATED-TO:P21716 , UniProt:RELATED-TO:P21717 , UniProt:RELATED-TO:P21718 , UniProt:RELATED-TO:P21719 , UniProt:RELATED-TO:P21720 , UniProt:RELATED-TO:P21721 , UniProt:RELATED-TO:P21722 , UniProt:RELATED-TO:P21723 , UniProt:RELATED-TO:P22289 , UniProt:RELATED-TO:P22695 , UniProt:RELATED-TO:P23004 , UniProt:RELATED-TO:P23134 , UniProt:RELATED-TO:P23135 , UniProt:RELATED-TO:P23136 , UniProt:RELATED-TO:P23663 , UniProt:RELATED-TO:P24878 , UniProt:RELATED-TO:P24890 , UniProt:RELATED-TO:P24950 , UniProt:RELATED-TO:P24951 , UniProt:RELATED-TO:P24952 , UniProt:RELATED-TO:P24953 , UniProt:RELATED-TO:P24954 , UniProt:RELATED-TO:P24955 , UniProt:RELATED-TO:P24956 , UniProt:RELATED-TO:P24957 , UniProt:RELATED-TO:P24958 , UniProt:RELATED-TO:P24959 , UniProt:RELATED-TO:P24960 , UniProt:RELATED-TO:P24962 , UniProt:RELATED-TO:P24964 , UniProt:RELATED-TO:P24965 , UniProt:RELATED-TO:P24966 , UniProt:RELATED-TO:P24992 , UniProt:RELATED-TO:P25076 , UniProt:RELATED-TO:P26852 , UniProt:RELATED-TO:P29630 , UniProt:RELATED-TO:P29631 , UniProt:RELATED-TO:P29632 , UniProt:RELATED-TO:P29633 , UniProt:RELATED-TO:P29634 , UniProt:RELATED-TO:P29635 , UniProt:RELATED-TO:P29636 , UniProt:RELATED-TO:P29637 , UniProt:RELATED-TO:P29638 , UniProt:RELATED-TO:P29639 , UniProt:RELATED-TO:P29640 , UniProt:RELATED-TO:P29641 , UniProt:RELATED-TO:P29757 , UniProt:RELATED-TO:P31800 , UniProt:RELATED-TO:P31930 , UniProt:RELATED-TO:P32551 , UniProt:RELATED-TO:P34197 , UniProt:RELATED-TO:P34844 , UniProt:RELATED-TO:P34845 , UniProt:RELATED-TO:P34861 , UniProt:RELATED-TO:P34863 , UniProt:RELATED-TO:P37299 , UniProt:RELATED-TO:P37841 , UniProt:RELATED-TO:P38593 , UniProt:RELATED-TO:P38594 , UniProt:RELATED-TO:P41280 ... [212 more not displayed]

Credits:
Revised 26-Jul-2012 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Marres77: Marres CM, Slater EC (1977). "Polypeptide composition of purified QH2:cytochrome c oxidoreductase from beef-heart mitochondria." Biochim Biophys Acta 462(3);531-48. PMID: 597492

Rieske76: Rieske JS (1976). "Composition, structure, and function of complex III of the respiratory chain." Biochim Biophys Acta 456(2);195-247. PMID: 788795

Wikstrom81: Wikstrom M, Krab K, Saraste M (1981). "Proton-translocating cytochrome complexes." Annu Rev Biochem 50;623-55. PMID: 6267990


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, BIOCYC14B.