MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Homo sapiens : glutathione peroxidase 4 Inferred from experiment : GPX4

In Pathway: glutathione redox reactions I

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phospholipid-hydroperoxide glutathione peroxidase

Enzyme Commission Synonyms: peroxidation-inhibiting protein, PHGPX, peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing), phospholipid hydroperoxide glutathione peroxidase, hydroperoxide glutathione peroxidase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -26.941177 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A protein containing a selenocysteine residue. The products of action of EC lipoxygenase on phospholipids can act as acceptor; H2O2 can also act, but much more slowly (cf. EC glutathione peroxidase).

Citations: [Ursini85]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R03167

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , UniProt:RELATED-TO:O23814 , UniProt:RELATED-TO:O48646


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Ursini85: Ursini F, Maiorino M, Gregolin C (1985). "The selenoenzyme phospholipid hydroperoxide glutathione peroxidase." Biochim Biophys Acta 839(1);62-70. PMID: 3978121

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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