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MetaCyc Reaction: 1.11.1.12

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 1.11.1.12

Enzymes and Genes:

Homo sapiens: glutathione peroxidase 4Inferred from experiment: GPX4

In Pathway: glutathione-peroxide redox reactions

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phospholipid-hydroperoxide glutathione peroxidase

Enzyme Commission Synonyms: peroxidation-inhibiting protein, PHGPX, peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing), phospholipid hydroperoxide glutathione peroxidase, hydroperoxide glutathione peroxidase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -26.941177Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A protein containing a selenocysteine residue. The products of action of EC 1.13.11.12 lipoxygenase on phospholipids can act as acceptors; H2O2 can also act, but much more slowly (cf. EC 1.11.1.9 glutathione peroxidase).

Citations: [Ursini85]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R03167

Relationship Links: BRENDA:EC:1.11.1.12, ENZYME:EC:1.11.1.12, IUBMB-ExplorEnz:EC:1.11.1.12, UniProt:RELATED-TO:O23814, UniProt:RELATED-TO:O48646


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Ursini85: Ursini F, Maiorino M, Gregolin C (1985). "The selenoenzyme phospholipid hydroperoxide glutathione peroxidase." Biochim Biophys Acta 839(1);62-70. PMID: 3978121


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sun Feb 7, 2016, biocyc11.