Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

MetaCyc Reaction: 1.14.19.5

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.14.19.5

Enzymes and Genes:
acyl-CoA Z11 / Δ10,12 desaturase Inferred from experiment : Bmpgdesat1 ( Bombyx mori )
acyl-CoA Δ11-desaturase Inferred from experiment : D11DS ( Trichoplusia ni )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: Δ11-fatty-acid desaturase

Enzyme Commission Synonyms: δ11 desaturase, fatty acid δ11-desaturase, TpDESN, Cro-PG, δ11 fatty acid desaturase, Z/E11-desaturase, δ11-palmitoyl-CoA desaturase

Enzyme Commission Summary:
In common with front-end desaturases involved in the synthesis of polyunsaturated fatty acids (PUFAs), this membrane-bound enzyme has a cytochrome b5-like domain at the N-terminus and contains three histidine boxes that are critical for desaturase activity. The enzyme from the marine microalga Thalassiosira pseudonana specifically desaturates palmitic acid 16:0 to 16:1-Delta(11) whereas that from the leafroller moth Choristoneura rosaceana desaturates myristic acid 14:0 to 14:1-Delta(11). 16:1-Delta(11) represents an important precursor for pheromone synthesis in insect cells, although its function in microalgae is currently unknown. The enzyme from the Egyptian cotton leafworm Spodoptera littoralis has a preference for palmitoyl-CoA as substrate and for NADH rather than NADPH as reduced acceptor.

Citations: [Tonon04]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:1.14.19.5 , ENZYME:EC:1.14.19.5 , IUBMB-ExplorEnz:EC:1.14.19.5


References

Tonon04: Tonon T, Harvey D, Qing R, Li Y, Larson TR, Graham IA (2004). "Identification of a fatty acid Delta11-desaturase from the microalga Thalassiosira pseudonana." FEBS Lett 563(1-3);28-34. PMID: 15063718


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, biocyc14.