|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
|Bombyx mori:||acyl-CoA 11-desaturase/conjugase: Bmpgdesat1|
|Trichoplusia ni:||acyl-CoA 11-desaturase: D11DS|
Supersedes EC number: 22.214.171.124
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Marked as unbalanced.
Enzyme Commission Primary Name: acyl-CoA 11-(Z)-desaturase
Enzyme Commission Synonyms: δ11 desaturase, fatty acid δ11-desaturase, TpDESN, Cro-PG, δ11 fatty acid desaturase, Z/E11-desaturase, δ11-palmitoyl-CoA desaturase, Δ11-fatty-acid desaturase
Taxonomic Range: Metazoa
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -35.015137 [Latendresse13]
Enzyme Commission Summary:
The enzyme introduces a cis double bond at position C11 of saturated fatty acyl-CoAs. In moths the enzyme participates in the biosynthesis of their sex pheromones. The enzyme from the marine microalga Thalassiosira pseudonana is specific for palmitoyl-CoA (16:0) [Tonon04], that from the leafroller moth Choristoneura rosaceana desaturates myristoyl-CoA (14:0) [Hao02], while that from the moth Spodoptera littoralis accepts both substrates [Martinez90]. The enzyme contains three histidine boxes that are conserved in all desaturases [Rodriguez92]. It is membrane-bound, and contains a cytochrome b5-like domain at the N-terminus that serves as the electron donor for the active site of the desaturase.
Navarro97: Navarro, I., Font, I., Fabrias, G., Camps, F. (1997). "Stereospecificity of the (E)- and (Z)-11 myristoyl desaturases in the biosynthesis of Spodoptera littoralis sex pheromone." J. Am. Chem. Soc. 119:11335-11336.
Rodriguez92: Rodriguez, F., Hallahan, D.L., Pickett, J.A., Camps, F. (1992). "Characterization of the Δ11-palmitoyl-CoA-desaturase from Spodoptera littoralis (Lepidoptera:Noctuidae)." Insect Biochem. Mol. Biol. 22: 143-148.
Tonon04: Tonon T, Harvey D, Qing R, Li Y, Larson TR, Graham IA (2004). "Identification of a fatty acid Delta11-desaturase from the microalga Thalassiosira pseudonana." FEBS Lett 563(1-3);28-34. PMID: 15063718
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