MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Candida boidinii: formate dehydrogenaseInferred from experiment: FDH1
Cupriavidus oxalaticus: NAD-dependent formate dehydrogenaseInferred from experiment
Gottschalkia acidurici: NAD-dependent formate dehydrogenaseInferred from experiment
Methylobacterium extorquens AM1: NAD-dependent formate dehydrogenaseInferred from experiment: fdh1A, fdh1B
Methylosinus trichosporium OB3b: NAD-dependent formate dehydrogenaseInferred from experiment
NAD-dependent formate dehydrogenaseInferred from experiment
Moraxella sp.: NAD-dependent formate dehydrogenaseInferred from experiment: fdh

In Pathway: oxalate degradation III, purine nucleobases degradation I (anaerobic), purine nucleobases degradation II (anaerobic), formate oxidation to CO2

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: formate dehydrogenase

Enzyme Commission Synonyms: formate-NAD oxidoreductase, FDH I, FDH II, N-FDH, formic hydrogen-lyase, formate hydrogenlyase, hydrogenlyase, NAD-linked formate dehydrogenase, NAD-dependent formate dehydrogenase, formate dehydrogenase (NAD), NAD-formate dehydrogenase, formate benzyl-viologen oxidoreductase, formic acid dehydrogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -5.1540833Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme from most aerobic organisms is devoid of redox-active centres but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centres, flavin and a molybdenum centre [Jollie91]. Together with EC, hydrogen dehydrogenase it forms a system previously known as formate hydrogenlyase.

Citations: [DAVISON51]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R00519, Rhea:15985

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


DAVISON51: DAVISON DC (1951). "Studies on plant formic dehydrogenase." Biochem J 49(4);520-6. PMID: 14886318

Jollie91: Jollie DR, Lipscomb JD (1991). "Formate dehydrogenase from Methylosinus trichosporium OB3b. Purification and spectroscopic characterization of the cofactors." J Biol Chem 266(32);21853-63. PMID: 1657982

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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