Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
twitter

MetaCyc Reaction: 1.2.1.2

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.2.1.2

Enzymes and Genes:
formate dehydrogenase Inferred from experiment : FDH1 ( Candida boidinii )
NAD-dependent formate dehydrogenase Inferred from experiment ( Cupriavidus oxalaticus )
NAD-dependent formate dehydrogenase Inferred from experiment ( Gottschalkia acidurici )
NAD-dependent formate dehydrogenase Inferred from experiment : fdh1A , fdh1B ( Methylobacterium extorquens AM1 )
NAD-dependent formate dehydrogenase Inferred from experiment ( Methylosinus trichosporium OB3b )
NAD-dependent formate dehydrogenase Inferred from experiment ( Methylosinus trichosporium OB3b )
NAD-dependent formate dehydrogenase Inferred from experiment : fdh ( Moraxella )

In Pathway: oxalate degradation III , purine nucleobases degradation I (anaerobic) , purine nucleobases degradation II (anaerobic) , formate oxidation to CO2

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: formate dehydrogenase

Enzyme Commission Synonyms: formate-NAD oxidoreductase, FDH I, FDH II, N-FDH, formic hydrogen-lyase, formate hydrogenlyase, hydrogenlyase, NAD-linked formate dehydrogenase, NAD-dependent formate dehydrogenase, formate dehydrogenase (NAD), NAD-formate dehydrogenase, formate benzyl-viologen oxidoreductase, formic acid dehydrogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -5.1540833 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme from most aerobic organisms is devoid of redox-active centres but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centres, flavin and a molybdenum centre [Jollie91]. Together with EC 1.12.1.2 hydrogen dehydrogenase, forms a system previously known as formate hydrogenlyase.

Citations: [DAVISON51]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R00519 , Rhea:15985

Relationship Links: BRENDA:EC:1.2.1.2 , ENZYME:EC:1.2.1.2 , IUBMB-ExplorEnz:EC:1.2.1.2


References

DAVISON51: DAVISON DC (1951). "Studies on plant formic dehydrogenase." Biochem J 49(4);520-6. PMID: 14886318

Jollie91: Jollie DR, Lipscomb JD (1991). "Formate dehydrogenase from Methylosinus trichosporium OB3b. Purification and spectroscopic characterization of the cofactors." J Biol Chem 266(32);21853-63. PMID: 1657982

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, biocyc11.