|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 126.96.36.199
Enzymes and Genes:
|Candida boidinii :||formate dehydrogenase
|Cupriavidus oxalaticus :||NAD-dependent formate dehydrogenase
|Gottschalkia acidurici :||NAD-dependent formate dehydrogenase
|Methylobacterium extorquens AM1 :||NAD-dependent formate dehydrogenase
|Methylosinus trichosporium OB3b :||NAD-dependent formate dehydrogenase
NAD-dependent formate dehydrogenase
|Moraxella ||NAD-dependent formate dehydrogenase
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: formate dehydrogenase
Enzyme Commission Synonyms: formate-NAD oxidoreductase, FDH I, FDH II, N-FDH, formic hydrogen-lyase, formate hydrogenlyase, hydrogenlyase, NAD-linked formate dehydrogenase, NAD-dependent formate dehydrogenase, formate dehydrogenase (NAD), NAD-formate dehydrogenase, formate benzyl-viologen oxidoreductase, formic acid dehydrogenase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -5.1540833 [Latendresse13]
Enzyme Commission Summary:
The enzyme from most aerobic organisms is devoid of redox-active centres but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centres, flavin and a molybdenum centre [Jollie91]. Together with EC 188.8.131.52 hydrogen dehydrogenase, forms a system previously known as formate hydrogenlyase.
Jollie91: Jollie DR, Lipscomb JD (1991). "Formate dehydrogenase from Methylosinus trichosporium OB3b. Purification and spectroscopic characterization of the cofactors." J Biol Chem 266(32);21853-63. PMID: 1657982
©2015 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493