|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
Enzymes and Genes:
|Candida boidinii:||formate dehydrogenase: FDH1|
|Cupriavidus oxalaticus:||NAD-dependent formate dehydrogenase|
|Gottschalkia acidurici:||NAD-dependent formate dehydrogenase|
|Methylobacterium extorquens AM1:||NAD-dependent formate dehydrogenase: fdh1A, fdh1B|
|Methylosinus trichosporium OB3b:||NAD-dependent formate dehydrogenase|
NAD-dependent formate dehydrogenase
|Moraxella sp.:||NAD-dependent formate dehydrogenase: fdh|
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: formate dehydrogenase
Enzyme Commission Synonyms: formate-NAD oxidoreductase, FDH I, FDH II, N-FDH, formic hydrogen-lyase, formate hydrogenlyase, hydrogenlyase, NAD-linked formate dehydrogenase, NAD-dependent formate dehydrogenase, formate dehydrogenase (NAD), NAD-formate dehydrogenase, formate benzyl-viologen oxidoreductase, formic acid dehydrogenase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -5.1540833 [Latendresse13]
Enzyme Commission Summary:
The enzyme from most aerobic organisms is devoid of redox-active centres but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centres, flavin and a molybdenum centre [Jollie91]. Together with EC 184.108.40.206, hydrogen dehydrogenase it forms a system previously known as formate hydrogenlyase.
Jollie91: Jollie DR, Lipscomb JD (1991). "Formate dehydrogenase from Methylosinus trichosporium OB3b. Purification and spectroscopic characterization of the cofactors." J Biol Chem 266(32);21853-63. PMID: 1657982
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