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MetaCyc Reaction: 1.2.7.5

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 1.2.7.5

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aldehyde ferredoxin oxidoreductase

Enzyme Commission Synonyms: AOR

Taxonomic Range: Archaea

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.707764 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This is an oxygen-sensitive enzyme that contains tungsten-molybdopterin and iron-sulfur clusters. Catalyses the oxidation of aldehydes (including crotonaldehyde, acetaldehyde, formaldehyde and glyceraldehyde) to their corresponding acids. However, it does not oxidize glyceraldehyde 3-phosphate [see EC 1.2.7.6, glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)]. Can use ferredoxin or methyl viologen but not NAD(P)+ as electron acceptor.

Citations: [Mukund91, Johnson93a, Chan95a, Roy01]

Unification Links: KEGG:R07158

Relationship Links: BRENDA:EC:1.2.7.5 , ENZYME:EC:1.2.7.5 , IUBMB-ExplorEnz:EC:1.2.7.5

Credits:
Revised 16-Sep-2011 by Caspi R , SRI International


References

Chan95a: Chan MK, Mukund S, Kletzin A, Adams MW, Rees DC (1995). "Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase." Science 267(5203);1463-9. PMID: 7878465

Johnson93a: Johnson JL, Rajagopalan KV, Mukund S, Adams MW (1993). "Identification of molybdopterin as the organic component of the tungsten cofactor in four enzymes from hyperthermophilic Archaea." J Biol Chem 268(7);4848-52. PMID: 8444863

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Mukund91: Mukund S, Adams MW (1991). "The novel tungsten-iron-sulfur protein of the hyperthermophilic archaebacterium, Pyrococcus furiosus, is an aldehyde ferredoxin oxidoreductase. Evidence for its participation in a unique glycolytic pathway." J Biol Chem 266(22);14208-16. PMID: 1907273

Roy01: Roy R, Menon AL, Adams MW (2001). "Aldehyde oxidoreductases from Pyrococcus furiosus." Methods Enzymol 331;132-44. PMID: 11265456


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon May 25, 2015, BIOCYC13A.