MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Supersedes EC number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aldehyde dehydrogenase (quinone)

Enzyme Commission Synonyms: aldehyde dehydrogenase (acceptor)

Standard Gibbs Free Energy (ΔrG): 5.5617523 kcal/molInferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Wide specificity; acts on straight-chain aldehydes up to C10, aromatic aldehydes, glyoxylate and glyceraldehyde. The enzymes contains a pyrroloquinoline quinone cofactor and multiple hemes that deliver the electrons to the membrane quinone pool.

Citations: [Ameyama82, Ameyama81, Patel80, GomezManzo10]

Unification Links: KEGG:R00544

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, Rhea:RELATED-TO:13881, UniProt:RELATED-TO:P17201


Ameyama81: Ameyama, M., Osada, K., Shinagawa, E., Matsushita, K., Adachi, O. (1981). "Purification and characterization of aldehyde dehydrogenase of Acetobacter aceti." Agric. Biol. Chem. 45:1189-1890.

Ameyama82: Ameyama, M., Adachi, O. (1982). "Aldehyde dehydrogenase from acetic acid bacteria, membrane-bound." Methods Enzymol. 89:491-497.

GomezManzo10: Gomez-Manzo S, Chavez-Pacheco JL, Contreras-Zentella M, Sosa-Torres ME, Arreguin-Espinosa R, Perez de la Mora M, Membrillo-Hernandez J, Escamilla JE (2010). "Molecular and catalytic properties of the aldehyde dehydrogenase of Gluconacetobacter diazotrophicus, a quinoheme protein containing pyrroloquinoline quinone, cytochrome b, and cytochrome c." J Bacteriol 192(21);5718-24. PMID: 20802042

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Patel80: Patel RN, Hou CT, Derelanko P, Felix A (1980). "Purification and properties of a heme-containing aldehyde dehydrogenase from Methylosinus trichosporium." Arch Biochem Biophys 203(2);654-62. PMID: 6779711

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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