MetaCyc Reaction: 1.2.5.c

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.2.5.c

Supersedes EC number:

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aldehyde dehydrogenase (quinone)

Standard Gibbs Free Energy (ΔrG in kcal/mol): 5.5617523 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Wide specificity; acts on straight-chain aldehydes up to C10, aromatic aldehydes, glyoxylate and glyceraldehyde. The enzymes contains a pyrroloquinoline quinone cofactor and multiple hemes that deliver the electrons to the membrane quinone pool.

Citations: [Ameyama82, Ameyama81, Patel80a, GomezManzo10]

Unification Links: KEGG:R00544

Relationship Links: Rhea:RELATED-TO:13881 , UniProt:RELATED-TO:P17201


Ameyama81: Ameyama, M., Osada, K., Shinagawa, E., Matsushita, K., Adachi, O. (1981). "Purification and characterization of aldehyde dehydrogenase of Acetobacter aceti." Agric. Biol. Chem. 45:1189-1890.

Ameyama82: Ameyama, M., Adachi, O. (1982). "Aldehyde dehydrogenase from acetic acid bacteria, membrane-bound." Methods Enzymol. 89:491-497.

GomezManzo10: Gomez-Manzo S, Chavez-Pacheco JL, Contreras-Zentella M, Sosa-Torres ME, Arreguin-Espinosa R, Perez de la Mora M, Membrillo-Hernandez J, Escamilla JE (2010). "Molecular and catalytic properties of the aldehyde dehydrogenase of Gluconacetobacter diazotrophicus, a quinoheme protein containing pyrroloquinoline quinone, cytochrome b, and cytochrome c." J Bacteriol 192(21);5718-24. PMID: 20802042

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Patel80a: Patel RN, Hou CT, Derelanko P, Felix A (1980). "Purification and properties of a heme-containing aldehyde dehydrogenase from Methylosinus trichosporium." Arch Biochem Biophys 203(2);654-62. PMID: 6779711

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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