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Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store

MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Supersedes EC number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aldehyde dehydrogenase (quinone)

Standard Gibbs Free Energy (ΔrG in kcal/mol): 5.5617523Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Wide specificity; acts on straight-chain aldehydes up to C10, aromatic aldehydes, glyoxylate and glyceraldehyde. The enzymes contains a pyrroloquinoline quinone cofactor and multiple hemes that deliver the electrons to the membrane quinone pool.

Citations: [Ameyama82, Ameyama81, Patel80a, GomezManzo10]

Unification Links: KEGG:R00544

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, Rhea:RELATED-TO:13881, UniProt:RELATED-TO:P17201


Ameyama81: Ameyama, M., Osada, K., Shinagawa, E., Matsushita, K., Adachi, O. (1981). "Purification and characterization of aldehyde dehydrogenase of Acetobacter aceti." Agric. Biol. Chem. 45:1189-1890.

Ameyama82: Ameyama, M., Adachi, O. (1982). "Aldehyde dehydrogenase from acetic acid bacteria, membrane-bound." Methods Enzymol. 89:491-497.

GomezManzo10: Gomez-Manzo S, Chavez-Pacheco JL, Contreras-Zentella M, Sosa-Torres ME, Arreguin-Espinosa R, Perez de la Mora M, Membrillo-Hernandez J, Escamilla JE (2010). "Molecular and catalytic properties of the aldehyde dehydrogenase of Gluconacetobacter diazotrophicus, a quinoheme protein containing pyrroloquinoline quinone, cytochrome b, and cytochrome c." J Bacteriol 192(21);5718-24. PMID: 20802042

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Patel80a: Patel RN, Hou CT, Derelanko P, Felix A (1980). "Purification and properties of a heme-containing aldehyde dehydrogenase from Methylosinus trichosporium." Arch Biochem Biophys 203(2);654-62. PMID: 6779711

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Thu Feb 11, 2016, biocyc14.