MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: aldehyde dehydrogenaseInferred from experiment: paoA, paoB, paoC

Reaction Locations: periplasm (sensu Gram-negative Bacteria)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aldehyde dehydrogenase (FAD-independent)

Enzyme Commission Synonyms: aldehyde oxidase, aldehyde oxidoreductase, Mop, AORDd

Taxonomic Range: Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): -27.93158Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Belongs to the xanthine oxidase family of enzymes.

Citations: [Andrade00, Duarte00, Uchida03, Romao95]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R00544

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, Rhea:RELATED-TO:13881


Andrade00: Andrade SL, Brondino CD, Feio MJ, Moura I, Moura JJ (2000). "Aldehyde oxidoreductase activity in Desulfovibrio alaskensis NCIMB 13491 EPR assignment of the proximal [2Fe-2S] cluster to the Mo site." Eur J Biochem 267(7);2054-61. PMID: 10727945

Duarte00: Duarte RO, Archer M, Dias JM, Bursakov S, Huber R, Moura I, Romao MJ, Moura JJ (2000). "Biochemical/spectroscopic characterization and preliminary X-ray analysis of a new aldehyde oxidoreductase isolated from Desulfovibrio desulfuricans ATCC 27774." Biochem Biophys Res Commun 268(3);745-9. PMID: 10679276

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Romao95: Romao MJ, Archer M, Moura I, Moura JJ, LeGall J, Engh R, Schneider M, Hof P, Huber R (1995). "Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas." Science 270(5239);1170-6. PMID: 7502041

Uchida03: Uchida H, Kondo D, Yamashita A, Nagaosa Y, Sakurai T, Fujii Y, Fujishiro K, Aisaka K, Uwajima T (2003). "Purification and characterization of an aldehyde oxidase from Pseudomonas sp. KY 4690." FEMS Microbiol Lett 229(1);31-6. PMID: 14659539

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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