Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.2.1.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.2.1.1

Enzymes and Genes:
transketolase I Inferred from experiment : tktA ( Escherichia coli K-12 substr. MG1655 )
transketolase II Inferred from experiment : tktB ( Escherichia coli K-12 substr. MG1655 )
transketolase Inferred from experiment : tktA ( Mycoplasma pneumoniae M129 )
transketolase : tktA ( Synechocystis sp. PCC 6803 )

In Pathway: pentose phosphate pathway (partial) , formaldehyde assimilation II (RuMP Cycle) , formaldehyde assimilation III (dihydroxyacetone cycle) , Bifidobacterium shunt , pentose phosphate pathway (non-oxidative branch) , Rubisco shunt , Calvin-Benson-Bassham cycle

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: transketolase

Enzyme Commission Synonyms: glycolaldehydetransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 1.2300415 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A thiamine-diphosphate protein. Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO2 and R-CHOH-CO-CH2OH. Transketolase from Alkaligenes faecalis shows high activity with D-erythrose as acceptor.

Citations: [DE55, HORECKER56, Racker61, Domagk65]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R01641 , Rhea:10508

Relationship Links: BRENDA:EC:2.2.1.1 , ENZYME:EC:2.2.1.1 , IUBMB-ExplorEnz:EC:2.2.1.1 , UniProt:RELATED-TO:O20250 , UniProt:RELATED-TO:O78327 , UniProt:RELATED-TO:P21725 , UniProt:RELATED-TO:P21726 , UniProt:RELATED-TO:P22976 , UniProt:RELATED-TO:P23254 , UniProt:RELATED-TO:P27302 , UniProt:RELATED-TO:P29277 , UniProt:RELATED-TO:P29401 , UniProt:RELATED-TO:P33315 , UniProt:RELATED-TO:P33570 , UniProt:RELATED-TO:P34736 , UniProt:RELATED-TO:P43757 , UniProt:RELATED-TO:P45694 , UniProt:RELATED-TO:P46708 , UniProt:RELATED-TO:P47312 , UniProt:RELATED-TO:P73282 , UniProt:RELATED-TO:P75611 , UniProt:RELATED-TO:Q9CF56 , UniProt:RELATED-TO:Q9JTR1 , UniProt:RELATED-TO:Q9PM31 , UniProt:RELATED-TO:Q9RFB7 , UniProt:RELATED-TO:Q9URM2 , UniProt:RELATED-TO:Q9Z475 , UniProt:RELATED-TO:Q42675 , UniProt:RELATED-TO:Q42676 , UniProt:RELATED-TO:Q42677 , UniProt:RELATED-TO:Q49047 , UniProt:RELATED-TO:Q52723 , UniProt:RELATED-TO:Q58092 , UniProt:RELATED-TO:Q58094


References

DE55: DE LA HABA G, LEDER IG, RACKER E (1955). "Crystalline transketolase from bakers' yeast: isolation and properties." J Biol Chem 214(1);409-26. PMID: 14367398

Domagk65: Domagk GF, Horecker BL (1965). "Fructose and erythrose metabolism in Alcaligenes faecalis." Archives of Biochemistry and Biophysics 109(2);342-349.

HORECKER56: HORECKER BL, HURWITZ J, SMYRNIOTIS PZ (1956). "The role of xylulose 5-phosphate in the transketolase reaction." J Biol Chem 223(2);1009-19. PMID: 13385248

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Racker61: Racker E. (1961). "Transketolase." In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds), The Enzymes, 2nd edn, vol. 5, Academic Press, New York pp. 397-412.


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Nov 24, 2014, biocyc14.