MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Homo sapiens: phenylethanolamine N-methyltransferaseInferred from experiment: PNMT

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phenylethanolamine N-methyltransferase

Enzyme Commission Synonyms: noradrenaline N-methyltransferase, noradrenalin N-methyltransferase, norepinephrine methyltransferase, norepinephrine N-methyltransferase, phenethanolamine methyltransferase, phenethanolamine N-methyltransferase

Taxonomic Range: Metazoa

Standard Gibbs Free Energy (ΔrG in kcal/mol): -10.459999Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on various phenylethanolamines; converts noradrenaline into adrenaline.

Citations: [Axelrod62, Connett70]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R04033, Rhea:12176

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P10937, UniProt:RELATED-TO:P10938, UniProt:RELATED-TO:P11086


Axelrod62: Axelrod J (1962). "Purification and properties of phenylethanolamine-N-methyl transferase." J Biol Chem 237;1657-60. PMID: 13863458

Connett70: Connett RJ, Kirshner N (1970). "Purification and properties of bovine phenylethanolamine N-methyltransferase." J Biol Chem 245(2);329-34. PMID: 5412063

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Sun Nov 29, 2015, BIOCYC13A.