Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.1.1.28

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.1.1.28

Enzymes and Genes:
phenylethanolamine N-methyltransferase Inferred from experiment : PNMT ( Homo sapiens )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phenylethanolamine N-methyltransferase

Enzyme Commission Synonyms: noradrenaline N-methyltransferase, noradrenalin N-methyltransferase, norepinephrine methyltransferase, norepinephrine N-methyltransferase, phenethanolamine methyltransferase, phenethanolamine N-methyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -10.459999 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on various phenylethanolamines; converts noradrenaline into adrenaline.

Citations: [Axelrod62, Connett70]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R04033 , Rhea:12176

Relationship Links: BRENDA:EC:2.1.1.28 , ENZYME:EC:2.1.1.28 , IUBMB-ExplorEnz:EC:2.1.1.28 , UniProt:RELATED-TO:P10937 , UniProt:RELATED-TO:P10938 , UniProt:RELATED-TO:P11086


References

Axelrod62: Axelrod J (1962). "Purification and properties of phenylethanolamine-N-methyl transferase." J Biol Chem 237;1657-60. PMID: 13863458

Connett70: Connett RJ, Kirshner N (1970). "Purification and properties of bovine phenylethanolamine N-methyltransferase." J Biol Chem 245(2);329-34. PMID: 5412063

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, BIOCYC13B.