MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col : 3-ketoacyl-CoA thiolase : KAT2
Escherichia coli K-12 substr. MG1655 : Fad I component of anaerobic fatty acid oxidation complex : fadI
fatty acid oxidation complex, β component : fadA
Homo sapiens : trifunctional enzyme beta subunit, mitochondrial precursor : HADHB
Non-specific lipid-transfer protein : SCP2
mitochondrial 3-ketoacyl-CoA thiolase : ACAA2
peroxisomal 3-ketoacyl-CoA thiolase : ACAA1
Pseudomonas putida : β-ketoadipyl CoA thiolase : pcaF
Saccharomyces cerevisiae : 3-oxoacyl CoA thiolase : POT1

In Pathway: (8E,10E)-dodeca-8,10-dienol biosynthesis , Spodoptera littoralis pheromone biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: acetyl-CoA C-myristoyltransferase

Enzyme Commission Synonyms: Myristoyl-CoA C-acetyltransferase, 3-oxopalmitoyl-CoA hydrolase, 3-oxopalmitoyl-CoA-CoA acetyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 7.0599365 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A peroxisomal enzyme involved in branched chain fatty acid β-oxidation in peroxisomes. It differs from EC (propionyl-CoA C2-trimethyldecanoyltransferase) in not being active towards 3-oxopristanoyl-CoA.

Citations: [Miyazawa81]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [a 2,3,4-saturated fatty acyl CoA + acetyl-CoA ← a 3-oxoacyl-CoA + coenzyme A] (
i1: acetyl-CoA + myristoyl-CoA ← 3-oxo-palmitoyl-CoA + coenzyme A (

Unification Links: KEGG:R03991 , Rhea:18161

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Revised 05-Sep-2012 by Caspi R , SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Miyazawa81: Miyazawa S, Furuta S, Osumi T, Hashimoto T, Ui N (1981). "Properties of peroxisomal 3-ketoacyl-coA thiolase from rat liver." J Biochem (Tokyo) 90(2);511-9. PMID: 6117552

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Oct 4, 2015, biocyc14.