Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.3.1.155

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.3.1.155

Enzymes and Genes:
β-ketoadipyl CoA thiolase : pcaF ( Pseudomonas putida )
3-ketoacyl-CoA thiolase : KAT2 ( Arabidopsis thaliana col )
peroxisomal 3-ketoacyl-CoA thiolase : ACAA1 ( Homo sapiens )
mitochondrial 3-ketoacyl-CoA thiolase : ACAA2 ( Homo sapiens )
Non-specific lipid-transfer protein : SCP2 ( Homo sapiens )
trifunctional enzyme beta subunit, mitochondrial precursor : HADHB ( Homo sapiens )
3-oxoacyl CoA thiolase : POT1 ( Saccharomyces cerevisiae )
fatty acid oxidation complex, β component : fadA ( Escherichia coli K-12 substr. MG1655 )
Fad I component of anaerobic fatty acid oxidation complex : fadI ( Escherichia coli K-12 substr. MG1655 )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: acetyl-CoA C-myristoyltransferase

Enzyme Commission Synonyms: Myristoyl-CoA C-acetyltransferase, 3-oxopalmitoyl-CoA hydrolase, 3-oxopalmitoyl-CoA-CoA acetyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 7.0599365 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A peroxisomal enzyme involved in branched chain fatty acid β-oxidation in peroxisomes. It differs from EC 2.3.1.154 (propionyl-CoA C2-trimethyldecanoyltransferase) in not being active towards 3-oxopristanoyl-CoA.

Citations: [Miyazawa81]

Gene-Reaction Schematic: ?

Instance reaction of [a 2,3,4-saturated fatty acyl CoA + acetyl-CoA ↔ a 3-oxoacyl-CoA + coenzyme A] (2.3.1.16):
i1: acetyl-CoA + myristoyl-CoA = 3-oxo-palmitoyl-CoA + coenzyme A (2.3.1.155)

Unification Links: KEGG:R03991 , Rhea:18161

Relationship Links: BRENDA:EC:2.3.1.155 , ENZYME:EC:2.3.1.155 , IUBMB-ExplorEnz:EC:2.3.1.155

Credits:
Revised 05-Sep-2012 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Miyazawa81: Miyazawa S, Furuta S, Osumi T, Hashimoto T, Ui N (1981). "Properties of peroxisomal 3-ketoacyl-coA thiolase from rat liver." J Biochem (Tokyo) 90(2);511-9. PMID: 6117552


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, biocyc13.