MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: 3-ketoacyl-CoA thiolase: KAT2
Escherichia coli K-12 substr. MG1655: Fad I component of anaerobic fatty acid oxidation complex: fadI
fatty acid oxidation complex, β component: fadA
Homo sapiens: trifunctional enzyme beta subunit, mitochondrial precursor: HADHB
Non-specific lipid-transfer protein: SCP2
mitochondrial 3-ketoacyl-CoA thiolase: ACAA2
peroxisomal 3-ketoacyl-CoA thiolase: ACAA1
Pseudomonas putida: β-ketoadipyl CoA thiolase: pcaF
Saccharomyces cerevisiae: 3-oxoacyl CoA thiolase: POT1

In Pathway: (8E,10E)-dodeca-8,10-dienol biosynthesis, Spodoptera littoralis pheromone biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: acetyl-CoA C-myristoyltransferase

Enzyme Commission Synonyms: Myristoyl-CoA C-acetyltransferase, 3-oxopalmitoyl-CoA hydrolase, 3-oxopalmitoyl-CoA-CoA acetyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 7.0599365Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A peroxisomal enzyme involved in branched chain fatty acid β-oxidation in peroxisomes. It differs from EC (propionyl-CoA C2-trimethyldecanoyltransferase) in not being active towards 3-oxopristanoyl-CoA.

Citations: [Miyazawa81]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [a 2,3,4-saturated fatty acyl CoA + acetyl-CoA ← a 3-oxoacyl-CoA + coenzyme A] (
i1: acetyl-CoA + myristoyl-CoA ← 3-oxo-palmitoyl-CoA + coenzyme A (

Unification Links: KEGG:R03991, Rhea:18161

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Revised 05-Sep-2012 by Caspi R, SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Miyazawa81: Miyazawa S, Furuta S, Osumi T, Hashimoto T, Ui N (1981). "Properties of peroxisomal 3-ketoacyl-coA thiolase from rat liver." J Biochem (Tokyo) 90(2);511-9. PMID: 6117552

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Mon Nov 30, 2015, BIOCYC14A.