Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 2.3.1.155

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.3.1.155

Enzymes and Genes:
β-ketoadipyl CoA thiolase : pcaF ( Pseudomonas putida )
3-ketoacyl-CoA thiolase : KAT2 ( Arabidopsis thaliana col )
peroxisomal 3-ketoacyl-CoA thiolase : ACAA1 ( Homo sapiens )
mitochondrial 3-ketoacyl-CoA thiolase : ACAA2 ( Homo sapiens )
Non-specific lipid-transfer protein : SCP2 ( Homo sapiens )
trifunctional enzyme beta subunit, mitochondrial precursor : HADHB ( Homo sapiens )
3-oxoacyl CoA thiolase : POT1 ( Saccharomyces cerevisiae )
fatty acid oxidation complex, β component : fadA ( Escherichia coli K-12 substr. MG1655 )
Fad I component of anaerobic fatty acid oxidation complex : fadI ( Escherichia coli K-12 substr. MG1655 )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: acetyl-CoA C-myristoyltransferase

Enzyme Commission Synonyms: Myristoyl-CoA C-acetyltransferase, 3-oxopalmitoyl-CoA hydrolase, 3-oxopalmitoyl-CoA-CoA acetyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 7.0599365 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A peroxisomal enzyme involved in branched chain fatty acid β-oxidation in peroxisomes. It differs from EC 2.3.1.154 (propionyl-CoA C2-trimethyldecanoyltransferase) in not being active towards 3-oxopristanoyl-CoA.

Citations: [Miyazawa81]

Gene-Reaction Schematic: ?

Instance reaction of [a 2,3,4-saturated fatty acyl CoA + acetyl-CoA ↔ a 3-oxoacyl-CoA + coenzyme A] (2.3.1.16):
i1: acetyl-CoA + myristoyl-CoA = 3-oxo-palmitoyl-CoA + coenzyme A (2.3.1.155)

Unification Links: KEGG:R03991 , Rhea:18161

Relationship Links: BRENDA:EC:2.3.1.155 , ENZYME:EC:2.3.1.155 , IUBMB-ExplorEnz:EC:2.3.1.155

Credits:
Revised 05-Sep-2012 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Miyazawa81: Miyazawa S, Furuta S, Osumi T, Hashimoto T, Ui N (1981). "Properties of peroxisomal 3-ketoacyl-coA thiolase from rat liver." J Biochem (Tokyo) 90(2);511-9. PMID: 6117552


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, biocyc14.